Alternaria as a major allergen for asthma in children raised in a desert environment
Alternaria as a major allergen for asthma in children raised in a desert environment
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DOI：
10.1164/ajrccm.155.4.9105079
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发表时间：
1997-04-01
影响因子：
24.7
通讯作者：
Martinez, FD
中科院分区：
文献类型：
--
作者：
Halonen, M;Stern, DA;Martinez, FD
在半干旱环境中长大的儿童中，哮喘和过敏性鼻炎与个体即刻皮试反应的关系被检测为优先相关性和随年龄的变化。医生诊断的哮喘患病率在6岁时为9.8%(n=948)，在11岁时为15.5%(n=895)。在患有变应性鼻炎的儿童和对照组中，对狗牙根草的即刻皮试反应最常见，而对霉菌交链孢霉的反应在哮喘患者中最常见。粗粉尘、粉尘尘埃和猫的皮肤试验反应在所有组中均较低。Logistic回归分析显示，在6岁和11岁时，交链孢属是唯一与哮喘风险增加独立相关的过敏原。变应性鼻炎在11岁时与对百慕大草和桑树花粉的致敏独立相关，但在6岁时与任何单一变应原没有独立关系。Logistic回归进一步表明，持续性哮喘(在6岁之前诊断)与6岁和11岁时的交链孢属皮肤试验独立相关。而新的哮喘(6岁后被诊断)与链格孢霉皮试有关，但在11岁时不是。我们得出结论，交链孢霉是与在半干旱环境中长大的儿童哮喘发生有关的主要过敏原，6岁时的皮试反应与哮喘的联系比11岁时更密切。
The relationships of asthma and allergic rhinitis with individual immediate skin test responses were examined for preferential associations and for changes with age in children raised in a semiarid environment. Prevalence of physician-diagnosed asthma was 9.8% at age 6 (n = 948) and 15.5% at age 11 (n = 895). immediate skin test responses to Bermuda grass were the most prevalent among children with allergic rhinitis and control subjects, whereas responses to the mold, Alternaria alternata, were the most prevalent among asthmatics. Skin test responses for crude house dust, Dermatophagoides farinae, and cat had low prevalences in all groups. By logistic regression, Alternaria was the only allergen independently associated with increased risk for asthma at both ages 6 and 11. Allergic rhinitis showed independent association with sensitization to Bermuda grass and mulberry tree pollen at age 11 but did not show an independent relation to any single allergen at age 6. Logistic regression further revealed that persistent asthma (diagnosed before age 6) was independently associated with Alternaria skin tests at both ages 6 and 11, whereas new asthma (diagnosed after age 6) was associated with Alternaria skin tests at age 6 but not at age 11. We conclude that Alternaria is the major allergen associated with the development of asthma in children raised in a semiarid environment and that skin test responses at age 6 are more closely linked to asthma than those at age 11.