Verification of cardiac tissue electrophysiology simulators using an N-version benchmark
Verification of cardiac tissue electrophysiology simulators using an N-version benchmark
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DOI：
10.1098/rsta.2011.0139
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发表时间：
2011-11-13
期刊：
影响因子：
5
通讯作者：
Smith, Nic P.
中科院分区：
文献类型：
--
作者：
Niederer, Steven A.;Kerfoot, Eric;Smith, Nic P.
心脏模型的持续发展尤其导致了用于模拟心脏组织电生理学的先进且日益复杂的计算框架的发展。这些模拟的目标通常是使用开发高性能计算体系结构的计算潜力的代码来表示心脏的详细生理和病理。这些发展迅速地提高了心脏虚拟生理人体模型的模拟能力；然而，它们也使得验证给定的代码提供了据称的控制方程和相应的求解技术的真实表示越来越具有挑战性。这项研究提供了第一个心脏组织电生理学模拟基准，以允许这些代码得到验证。该基准在11个仿真平台上成功地进行了评估，以生成一致的黄金标准融合解决方案。基准定义与黄金标准解决方案相结合，现在可以用来验证未来新的模拟代码和数值方法。
Ongoing developments in cardiac modelling have resulted, in particular, in the development of advanced and increasingly complex computational frameworks for simulating cardiac tissue electrophysiology. The goal of these simulations is often to represent the detailed physiology and pathologies of the heart using codes that exploit the computational potential of high-performance computing architectures. These developments have rapidly progressed the simulation capacity of cardiac virtual physiological human style models; however, they have also made it increasingly challenging to verify that a given code provides a faithful representation of the purported governing equations and corresponding solution techniques. This study provides the first cardiac tissue electrophysiology simulation benchmark to allow these codes to be verified. The benchmark was successfully evaluated on 11 simulation platforms to generate a consensus gold-standard converged solution. The benchmark definition in combination with the gold-standard solution can now be used to verify new simulation codes and numerical methods in the future.