Topical isotretinoin in Darier's disease
Topical isotretinoin in Darier's disease
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DOI：
10.1111/j.1365-2133.1995.tb06927.x
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发表时间：
1995-12-01
影响因子：
10.3
通讯作者：
Buxton, PK
中科院分区：
文献类型：
--
作者：
Burge, SM;Buxton, PK
外用0.05%异维甲酸(异维A酸(R)凝胶)治疗11例Darier病患者的皮肤试验斑块，治疗3个月后6例角化过度和丘疹改善，红斑、灼热和刺激是常见的不良反应，3例严重，其中1例停止治疗。轻度Darier病的患者可能会发现外用异维A酸有帮助，但很可能大多数广泛性疾病的患者将需要全身性维甲酸治疗。
Topical 0.05% isotretinoin (Isotrex(R) gel) was used to treat a test patch of skin in 11 patients with Darier's disease, Hyperkeratosis and papules improved in six patients after treatment for 3 months, Erythema, burning and irritation were common adverse effects, and these were severe in three patients, one of whom stopped treatment. Patients with mild Darier's disease may find topical isotretinoin helpful, but it is likely that most patients with widespread disease will require treatment with systemic retinoids.