Relation between clinical characteristics of Parkinson's disease and cognitive decline
Relation between clinical characteristics of Parkinson's disease and cognitive decline
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DOI：
10.1076/jcen.25.1.94.13624
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发表时间：
2003-02-01
影响因子：
2.2
通讯作者：
Growdon, JH
中科院分区：
文献类型：
--
作者：
Locascio, JJ;Corkin, S;Growdon, JH
本研究探讨了帕金森病（PD）的认知障碍与临床特征（如测试年龄、疾病持续时间、运动障碍，尤其是发病年龄）的关系。为了解决这些问题，我们对104名PD患者和60名年龄和教育程度相当的健康志愿者进行了14项记忆、语言、视觉空间和额叶能力测试。参与者在1-10年内完成了1-9次测试。PD的持续时间与大多数认知测试中的表现恶化有关，与年龄相关的下降无关。在保持年龄和持续时间不变的情况下，以Hoehn和Yahr分期为指标的运动损伤严重程度与几乎所有认知测试中的损伤呈正相关。对于一些测试，特别是那些运动要求高的测试和那些评估语言技能的测试，认知缺陷在晚发性PD患者的病程中比早发性PD患者出现得更早。这些迟发性缺陷是协同效应，超出了疾病持续时间和正常衰老的累加性贡献。这些发现可能有助于医生向PD患者及其家属提供有关疾病未来病程的建议。
This study examined how cognitive impairments in Parkinson's disease (PD) are related to clinical characteristics such as age at testing, duration of illness, motor impairment, and especially age at disease onset. To address these issues, we administered 14 tests of memory, language, visuospatial, and frontal lobe capacities to 104 PD patients and 60 healthy volunteers of comparable age and education. The participants completed 1-9 test sessions over 1-10 years. Duration of PD was associated with deteriorating performance on most cognitive tests, independent of age-related decline. Severity of motor impairment, indexed by Hoehn and Yahr stages, was positively related to impairment on almost all cognitive tests, holding age and duration constant. For some tests, especially those that were motorically demanding and those that assessed language skills, cognitive deficits appeared earlier in the disease course for late-onset than for early-onset PD patients. These late onset deficits were synergistic effects beyond the additive contributions of disease duration and normal aging. These findings may assist physicians in advising PD patients and their families about the future course of the illness.