Total Systemic Vascular Compliance Measured as Incremental Volume‐Pressure Ratio
Total Systemic Vascular Compliance Measured as Incremental Volume‐Pressure Ratio
复制标题
以增量体积压力比测量总的全身血管顺应性
作者：
A. Shoukas;K. Sagawa
我们开发了一种方法来测量总体循环血管床（Ct）的顺应性，定义为ΔVΔP，而不停止体循环血流。在10只开胸犬中，通过在腔静脉和右心房之间插入灌注泵（无储液器），将静脉回流（和心输出量）维持在恒定水平。在45秒内从犬体内抽取约5%的估计总血量。在容量改变后10、30、60、120和180秒测量中心静脉压的变化。然后再输注流血的量，以重复类似的静脉压测量180秒。在稍微增加血容量或切断迷走神经后重复测量。迷走神经切断术前，出血或再灌注后10秒测得的Ct平均值为1.96 ± 0.10（SE）ml/mm Hg/kg体重。配对t检验表明，出血和再输注的测量值，不同的初始静脉压或血容量的测量值，或迷走神经切断术前后的测量值之间没有显着差异。然而，Ct在2分钟期间随时间增加，约为初始10秒值的25%（P<0.001），此后保持恒定。
We developed a method to measure the compliance, defined as ΔVΔP, of the total systemic vascular bed (Ct) without stopping systemic flow. In 10 open-chest dogs, venous return (and cardiac output) was maintained at a constant level by inserting a perfusion pump (with no reservoir) between the caval veins and the right atrium. About 5% of the estimated total blood volume was withdrawn from the dog within 45 seconds. Resultant changes in central venous pressure were measured 10, 30, 60, 120, and 180 seconds after the volume change. The bled volume was then reinfused to repeat similar venous pressure measurements for another 180 seconds. The measurements were repeated after slightly increasing the blood volume or sectioning the vagi. The mean value of Ct measured 10 seconds after hemorrhage or reinfusion was 1.96 ± 0.10 (SE) ml/mm Hg/kg body weight before vagotomy. Paired t-tests indicated no significant difference between measurements of bleeding and reinfusion, measurements with different initial venous pressures or blood volume, or measurements before and after vagotomy. However, Ct increased with time during the 2-minute period by about 25% of the initial 10-second value (P<0.001) and remained constant thereafter.