Investigation of Cerebral Autoregulation in the Newborn Piglet During Anaesthesia and Surgery
Investigation of Cerebral Autoregulation in the Newborn Piglet During Anaesthesia and Surgery
复制标题
新生仔猪麻醉和手术期间大脑自动调节的研究
DOI：
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发表时间：
2014
影响因子：
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通讯作者：
I. Tachtsidis
中科院分区：
文献类型：
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作者：
Gemma Bale;A. Oliver;I. Fierens;K. Broad;J. Hassell;G. Kawano;J. Rostami;G. Raivich;R. Sanders;N. Robertson;I. Tachtsidis
本文研究了脑自动调节（CA）与手术麻醉和非手术麻醉的神经毒性效应之间的关系。将新生仔猪随机分配接受6小时麻醉（异氟烷）或相同的麻醉，再进行1小时的小手术。平均动脉血压（MABP）的自发变化对脑血流动力学（氧合和脱氧血红蛋白，HbO 2和Hb）的影响，采用横向宽带近红外光谱（NIRS）测量。使用相干性分析评估CA受损的标志物，超低频域（0.0018-0.0083 Hz）中MABP和血管内氧合（HbD = HbO 2 − Hb）之间的一致性。CA损伤的存在并不显著，但发现随着手术恶化而增加。损伤与组织学结果（脑中存在细胞死亡、凋亡和小胶质细胞活化）无关。
The relationship between cerebral autoregulation (CA) and the neurotoxic effects of anaesthesia with and without surgery is investigated. Newborn piglets were randomly assigned to receive either 6 h of anaesthesia (isoflurane) or the same with an additional hour of minor surgery. The effect of the spontaneous changes in mean arterial blood pressure (MABP) on the cerebral haemodynamics (oxy- and deoxy-haemoglobin, HbO2 and Hb) was measured using transverse broadband near-infrared spectroscopy (NIRS). A marker for impaired CA, concordance between MABP and intravascular oxygenation (HbD = HbO2 − Hb) in the ultra-low frequency domain (0.0018–0.0083 Hz), was assessed using coherence analysis. Presence of CA impairment was not significant but found to increase with surgical exacerbation. The impairment did not correlate with histological outcome (presence of cell death, apoptosis and microglial activation in the brain).