Zn-Li alloy after extrusion and drawing: Structural, mechanical characterization, and biodegradation in abdominal aorta of rat.
Zn-Li alloy after extrusion and drawing: Structural, mechanical characterization, and biodegradation in abdominal aorta of rat.
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DOI：
10.1016/j.msec.2017.02.167
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发表时间：
2017-07-01
期刊：
影响因子：
--
通讯作者：
Drelich JW
中科院分区：
文献类型：
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作者：
Zhao S;Seitz JM;Eifler R;Maier HJ;Guillory RJ 2nd;Earley EJ;Drelich A;Goldman J;Drelich JW
锌作为一种生物可吸收金属显示出巨大的潜力。我们在Sprague-Dawley大鼠腹主动脉植入纯锌丝的早期体内研究发现，金属锌不会促进再狭窄反应，可能抑制炎症和平滑肌细胞的活动。然而，锌的低抗拉强度仍然是一个主要问题。采用真空感应连铸机在氩气气氛下制备锌锂合金铸坯，并进行拉丝工艺。x射线衍射鉴定出二元合金的锌相和金属间化合物LiZn4相。力学试验证明，掺入3 at。在纯Zn中加入% Li后，其抗拉强度由116±13 MPa（纯Zn）提高到274±61 MPa，而延展性保持在17±7%。将10 mm锌- 3li金属丝段植入大鼠腹主动脉，表明该材料在动脉环境中具有良好的生物相容性。在2个月和12个月时，Zn-3Li的生物降解率分别为0.008 mm/yr和0.045 mm/yr。
Zinc shows great promise as a bioabsorbable metal. Our early in vivo investigations implanting pure zinc wires into the abdominal aorta of Sprague-Dawley rats revealed that metallic zinc does not promote restenotic responses and may suppress the activities of inflammatory and smooth muscle cells. However, the low tensile strength of zinc remains a major concern. A cast billet of the Zn-Li alloy was produced in a vacuum induction caster under argon atmosphere, followed by a wire drawing process. Two phases of the binary alloy identified by x-ray diffraction include the zinc phase and intermetallic LiZn4 phase. Mechanical testing proved that incorporating 3 at.% of Li into Zn increased its ultimate tensile strength from 116 ± 13 MPa (pure Zn) to 274 ± 61 MPa while the ductility was held at 17 ± 7%. Implantation of 10 mm Zn-3Li wire segments into abdominal aorta of rats revealed an excellent biocompatibility of this material in the arterial environment. The biodegradation rate for Zn-3Li was found to be about 0.008 mm/yr and 0.045 mm/yr at 2 and 12 months, respectively.