Noninvasive MRI evaluation of cerebral blood flow in cerebrovascular disease
Noninvasive MRI evaluation of cerebral blood flow in cerebrovascular disease
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DOI：
10.1212/wnl.50.3.633
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发表时间：
1998-03-01
期刊：
影响因子：
9.9
通讯作者：
Raps, EC
中科院分区：
文献类型：
--
作者：
Detre, JA;Alsop, DC;Raps, EC
先前的研究表明，利用动脉水的磁性标记作为扩散性血流示踪剂，MRI可以无创地评估脑血流量(CBF)。本研究的目的是评估使用该方法从脑血管疾病患者获得的CBF图像的质量，并开始评估该技术的潜在临床应用价值。我们招募了14名患者，他们表现为中风、短暂性脑缺血发作或严重的颈动脉狭窄，根据临床评估很可能改变了脑血流。在其中许多患者中，CBF成像显示局灶性和半球低灌注，或者在血管区域，或者在分水岭区域。在11例近端动脉明显狭窄的患者中，大脑半球CBF异常位于最显著狭窄的前循环分布侧。在一些患者中，分水岭低灌注率甚至更明显。我们的结果表明，从脑血管疾病患者身上可以可靠地获得高质量的MR CBF图像。CBF成像可以在一次MRI检查中与标准结构成像相结合，并提供有临床意义的信息。脑血流量的测量为临床评估和卒中病理生理的进一步研究提供了一种潜在的有用工具。
Previous studies have demonstrated that cerebral blood flow (CBF) can be assessed noninvasively by MRI using magnetic labeling of arterial water as a diffusible flow tracer. The purpose of this study was to assess the quality of CBF images obtained from patients with cerebrovascular disease using this method, and to begin to evaluate the potential clinical role for this technique. We recruited 14 patients who presented with stroke, TIA, or severe carotid stenosis and were likely to have altered CBF based on clinical assessment. In many of these patients, CBF imaging disclosed both focal and hemispheric hypoperfusion, either in vascular territories or in watershed regions. In 11 patients with significant proximal arterial stenosis, hemispheric CBF abnormalities localized to the side of most significant stenosis for the anterior circulation distribution. In several patients watershed hypoperfusion was even more pronounced. Our results suggest that good-quality MR CBF images can be obtained reliably from patients with cerebrovascular disease. CBF imaging can be combined with standard structural imaging within a single MRI examination, and provides clinically meaningful information. The capability of measuring CBF easily provides a potentially useful tool for clinical assessment and further investigation of stroke pathophysiology.