Liver stiffness measured by magnetic resonance elastography as a risk factor for hepatocellular carcinoma: a preliminary case-control study
Liver stiffness measured by magnetic resonance elastography as a risk factor for hepatocellular carcinoma: a preliminary case-control study
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DOI：
10.1007/s00330-012-2571-6
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发表时间：
2013-01-01
影响因子：
5.9
通讯作者：
Araki, Tsutomu
中科院分区：
文献类型：
--
作者：
Motosugi, Utaroh;Ichikawa, Tomoaki;Araki, Tsutomu
为了研究磁共振弹性成像（MRE）测量的肝硬度是否是慢性肝病患者发生肝细胞癌（HCC）的危险因素，通过回顾在我们机构进行的磁共振（MR）检查记录，我们选择了301例既往无HCC病史的慢性肝病患者。所有患者均行磁共振成像和钆塞酸增强扫描。301例患者中有66例在MR图像上识别出HCC，根据年龄将其与其余无HCC患者的对照组相匹配。磁共振成像图像通过可视化弹性波产生的肝脏气动振动通过圆柱形被动驱动器传输。采用Logistic回归分析方法，以比值比确定肝癌发生的危险因素;通过MRE和血清天冬氨酸转移酶，丙氨酸转移酶，甲胎蛋白，多变量分析显示，只有MRE的肝硬度是HCC的重要危险因素，其比值比为（95%置信区间）为1.38（1.05-1.84）. MRE测量的肝硬度是慢性肝病患者发生HCC的独立危险因素。a欧分磁共振弹性成像可以估计肝硬度，肝硬化是肝细胞癌（HCC）的独立危险因素。与肿瘤标志物相比，肝硬度似乎是HCC的更好指标。
To examine if liver stiffness measured by magnetic resonance elastography (MRE) is a risk factor for hepatocellular carcinoma (HCC) in patients with chronic liver disease.By reviewing the records of magnetic resonance (MR) examinations performed at our institution, we selected 301 patients with chronic liver disease who did not have a previous medical history of HCC. All patients underwent MRE and gadoxetic acid-enhanced MR imaging. HCC was identified on MR images in 66 of the 301 patients, who were matched to controls from the remaining patients without HCC according to age. MRE images were obtained by visualising elastic waves generated in the liver by pneumatic vibration transferred via a cylindrical passive driver. Risk factors of HCC development were determined by the odds ratio with logistic regression analysis; gender and liver stiffness by MRE and serum levels of aspartate transferase, alanine transferase, alpha-fetoprotein, and protein induced by vitamin K absence-II.Multivariate analysis revealed that only liver stiffness by MRE was a significant risk factor for HCC with an odds ratio (95 % confidence interval) of 1.38 (1.05-1.84).Liver stiffness measured by MRE is an independent risk factor for HCC in patients with chronic liver disease.aEuro cent Magnetic resonance elastography can estimate liver stiffness, a marker of hepatic fibrosis.aEuro cent Liver stiffness is an independent risk factor of hepatocellular carcinoma (HCC).aEuro cent Liver stiffness seems a better indicator of HCC than tumour markers.