Metabolic replacement of kidney function in uremic animals with a bioartificial kidney containing human cells.
Metabolic replacement of kidney function in uremic animals with a bioartificial kidney containing human cells.
复制标题
用含有人类细胞的生物人工肾对尿毒症动物的肾功能进行代谢替代。
DOI：
10.1053/ajkd.2002.32792
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Gutierrez,JorgeM
中科院分区：
文献类型：
--
作者：
Humes,HDavid;Fissell,WilliamH;Weitzel,WilliamF;Buffington,DeborahA;Westover,AngelaJ;MacKay,SherrillM;Gutierrez,JorgeM
Current renal substitution therapy with hemodialysis or hemofiltration has been an important life-sustaining technology, but it still has suboptimal clinical outcomes in patients with end-stage renal disease or acute renal failure. This therapy replaces the small solute clearance function of the glomerulus but does not replace the metabolic and endocrinologic functions of the tubular cells. This article shows that the combination of a synthetic hemofiltration cartridge and a renal tubule cell assist device (RAD) containing human cells in an extracorporeal circuit replaces filtration, metabolic, and endocrinologic functions in acutely uremic dogs. The RAD maintained excellent performance and durability characteristics for 24 hours of continuous use in the uremic animals. The RAD increased ammonia excretion, glutathione metabolism, and 1,25-dihydroxyvitamin D3production. Cardiovascular stability in the animals was documented in these studies during this extracorporeal treatment. With these results, clinical evaluation of this device in the treatment of severely ill patients with acute renal failure in an intensive care unit has been initiated. © 2002 by the National Kidney Foundation, Inc.
