Glutamatergic synaptic integration of locomotion speed via septoentorhinal projections
Glutamatergic synaptic integration of locomotion speed via septoentorhinal projections
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DOI：
10.1038/nn.4447
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发表时间：
2017-01-01
影响因子：
25
通讯作者：
Remy, Stefan
中科院分区：
文献类型：
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作者：
Justus, Daniel;Daluegge, Dennis;Remy, Stefan
Broca内侧隔和斜角带(MSDB)将谷氨酸能轴突发送到内侧内嗅皮层(MEC)。我们发现，这条通路为层2/3中的几种MEC细胞提供与速度相关的输入。锥体细胞最有效地整合了速度信号，但也兴奋了星状细胞和中间神经元。因此，MSDB传递的速度信息可被MEC神经元用于自我定位的空间表示。
The medial septum and diagonal band of Broca (MSDB) send glutamatergic axons to medial entorhinal cortex (MEC). We found that this pathway provides speed-correlated input to several MEC cell-types in layer 2/3. The speed signal is integrated most effectively by pyramidal cells but also excites stellate cells and interneurons. Thus, the MSDB conveys speed information that can be used by MEC neurons for spatial representation of self-location.