Immune Reconstitution after Double Umbilical Cord Blood Stem Cell Transplantation: Comparison with Unrelated Peripheral Blood Stem Cell Transplantation
Immune Reconstitution after Double Umbilical Cord Blood Stem Cell Transplantation: Comparison with Unrelated Peripheral Blood Stem Cell Transplantation
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DOI：
10.1016/j.bbmt.2011.08.018
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发表时间：
2012-04-01
影响因子：
4.3
通讯作者：
Ritz, Jerome
中科院分区：
文献类型：
--
作者：
Jacobson, Caron A.;Turki, Amin T.;Ritz, Jerome
双脐带血（DUCB）移植是一种被接受的移植策略，用于没有合适的人类白细胞抗原（HLA）匹配供体的患者。然而，由于免疫恢复缓慢和感染风险高，DUCB移植与发病率和死亡率增加有关。为了确定DUCB移植和HLA匹配无关供者（MUD）移植在免疫重建方面的差异，我们对42例DUCB受体和102例非格昔汀动员的无关外周血干细胞受体的免疫重建进行了详细的前瞻性分析。移植后1 - 6个月，与MUD组相比，DUCB组的CD3 T细胞重构明显延迟(P
Double umbilical cord blood (DUCB) transplantation is an accepted transplantation strategy for patients without suitable human leukocyte antigen (HLA) matched donors. However, DUCB transplantation is associated with increased morbidity and mortality because of slow recovery of immunity and a high risk of infection. To define the differences in immune reconstitution between DUCB transplantation and HLA matched unrelated donor (MUD) transplantation, we performed a detailed, prospective analysis of immune reconstitution in 42 DUCB recipients and 102 filgrastim-mobilized unrelated peripheral blood stem cell recipients. Reconstitution of CD3 T cells was significantly delayed in the DUCB cohort compared with the MUD cohort for 1 to 6 months posttransplantation (P