Amphetamine modulates human incentive processing
Amphetamine modulates human incentive processing
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DOI：
10.1016/j.neuron.2004.06.030
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发表时间：
2004-07-22
期刊：
影响因子：
16.2
通讯作者：
Weinberger, DR
中科院分区：
文献类型：
--
作者：
Knutson, B;Bjork, JM;Weinberger, DR
研究表明，精神兴奋剂可以在生理上改变腹侧纹状体（VS）的多巴胺动力学，并在心理上增强情绪和注意力。使用事件相关功能磁共振成像 (fMRI)，我们进行了一项受试者内、双盲、安慰剂 (PLAC) 对照研究，研究口服右旋苯丙胺（AMPH，0.25 mg/kg）治疗对激励处理过程中大脑活动和影响的影响。在摄入 AMPH 或 PLAC 后 60-180 分钟的两次平衡扫描中，8 名健康志愿者玩了一个涉及金钱收益和损失的预期和接收的游戏。兴趣组和体积分析表明，通过增强强直性而非阶段性激活，AMPH 治疗“均衡”了 VS 活动水平和预期获得和损失期间的积极唤醒水平。这些发现表明，安非他明对激励处理的治疗作用可能涉及减少预期收益和损失之间的差异。
Research suggests that psychostimulants can physiologically alter dopamine kinetics in the ventral striatum (VS) and psychologically enhance mood and attention. Using event-related functional magnetic resonance imaging (fMRI), we conducted a within-subject, double-blind, placebo (PLAC)-controlled study of the effects of oral dextroamphetamine (AMPH, 0.25 mg/kg) treatment on brain activity and affect during incentive processing. In two counterbalanced scanning sessions 60-180 min after ingesting AMPH or PLAC, 8 healthy volunteers played a game involving anticipation and receipt of monetary gains and losses. Group and volume of interest analyses suggested that by enhancing tonic over phasic activation, AMPH treatment "equalized" levels of VS activity and positive arousal during anticipation of both gain and loss. These findings suggest that therapeutic effects of amphetamine on incentive processing may involve reducing the difference between anticipation of gains and losses.