Diastolic pressure determines autonomic responses to pressure perturbation in humans.
Diastolic pressure determines autonomic responses to pressure perturbation in humans.
复制标题
舒张压决定人类对压力扰动的自主反应。
DOI：
10.1152/jappl.1989.66.2.800
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Ferguson,DW
中科院分区：
文献类型：
--
作者：
Sanders,JS;Ferguson,DW
动脉压力感受器反射性地调节交感神经和心率对血压变化的反应。人类动脉压力感受器活动的主要机械决定因素仍不清楚。我们研究了10名正常人[年龄25 +/- 2（SE）yr]在动脉压扰动过程中收缩压、舒张压、脉搏压和平均动脉压对传出肌交感神经活动（MSNA，显微神经造影）和心率反应的影响。我们在静脉输注血管扩张剂（硝普钠，6 +/- 1 μ g·kg-1·min-1，n = 6;肼苯哒嗪，16 +/- 2 mg，n = 4）期间直接测量动脉压、心率和MSNA，同时通过容量扩张保持中心静脉压恒定。在血管扩张剂输注3分钟期间，我们观察到收缩压和脉压增加，同时平均压和舒张压降低，将动脉压的变化与心率和MSNA的变化进行比较。在血管扩张剂输注期间，（124.2 +/- 2.1至131.7 +/- 2.9 Torr，P小于0.001）和脉压（57.0 +/- 2.2至72.7 +/- 2.7 Torr，P小于0.001）尽管平均动脉压下降（88.0 +/- 2.6至80.4 +/- 2.7 Torr，P小于0.001），因为舒张压降低（67.2 +/- 3.0至59.0 +/- 2.7 Torr，P小于0.001）。动脉压的变化伴随着心率（66.4 +/- 3.0至92.6 +/- 4.8次/分，P <0.001）和MSNA（327 +/- 59至936 +/- 171 U，P <0.005）的同时增加。（250字处删节）
Arterial baroreceptors reflexly regulate sympathetic and heart rate responses to alteration of blood pressure. The primary mechanical determinant of arterial baroreceptor activity in humans remains unclear. We examined the influence of systolic, diastolic, pulse, and mean arterial pressures on efferent muscle sympathetic nerve activity (MSNA, microneurography) and heart rate responses during perturbation of arterial pressure in 10 normal human subjects [age 25 +/- 2 (SE) yr]. We directly measured arterial pressure, heart rate, and MSNA during intravenous vasodilator infusion (nitroprusside, 6 +/- 1 micrograms.kg-1.min-1, n = 6; or hydralazine, 16 +/- 2 mg, n = 4) while central venous pressure was held constant by simultaneous volume expansion. Changes in arterial pressures were compared with changes in heart rate and MSNA over 3-min periods of vasodilator infusion during which we observed increases in systolic and pulse pressures with simultaneous decreases in mean and diastolic pressures. During vasodilator infusion, there were increases in systolic (124.2 +/- 2.1 to 131.7 +/- 2.9 Torr, P less than 0.001) and pulse pressures (57.0 +/- 2.2 to 72.7 +/- 2.7 Torr, P less than 0.001) although mean arterial pressure fell (88.0 +/- 2.6 to 80.4 +/- 2.7 Torr, P less than 0.001) because of decreases in diastolic pressure (67.2 +/- 3.0 to 59.0 +/- 2.7 Torr, P less than 0.001). The changes in arterial pressures were accompanied by simultaneous increases in heart rate (66.4 +/- 3.0 to 92.6 +/- 4.8 beats/min, P less than 0.001) and MSNA (327 +/- 59 to 936 +/- 171 U, P less than 0.005).(ABSTRACT TRUNCATED AT 250 WORDS)