Roll out the barrel! Outer membrane tension resolves an unexpected folding intermediate.
Roll out the barrel! Outer membrane tension resolves an unexpected folding intermediate.
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滚出桶！
DOI：
10.1016/j.cell.2022.03.001
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发表时间：
2022
期刊：
影响因子：
64.5
通讯作者：
Horne JE
中科院分区：
文献类型：
--
作者：
Horne JE
在没有能源的情况下，细菌如何将跨膜β桶组装到它们的外膜中？Doyle等人的新结构和实验。提示β-Barrel组装机械利用膜弹性张力的力量来帮助完成β-Barrel外膜蛋白的折叠。
How do bacteria assemble transmembrane β-barrels into their outer membrane in the absence of an energy source? New structures and experiments from Doyle et al. suggest that the β-barrel assembly machinery (BAM) co-opts the power of membrane elastic tension to help complete the folding of β-barrel outer membrane proteins.