Does Cytomegalovirus Serology Impact Outcome After Pediatric Heart Transplantation?
Does Cytomegalovirus Serology Impact Outcome After Pediatric Heart Transplantation?
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DOI：
10.1016/j.healun.2009.07.011
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发表时间：
2009-12-01
影响因子：
8.9
通讯作者：
Kanter, Kirk R.
中科院分区：
文献类型：
--
作者：
Mahle, William T.;Fourshee, Margaret T.;Kanter, Kirk R.
背景：巨细胞病毒（CMV）感染与心脏移植术后的许多并发症有关。最近的一项研究表明，与CMV受体相比，移植前CMV血清学（CMV+）阳性的儿童发生同种异体冠状动脉血管病变（CAV）和死亡的风险增加。我们分析了儿童心脏移植研究组的数据，以确定受体巨细胞病毒状态和巨细胞病毒错配对结果的影响。此外，还对巨细胞病毒预防的使用和疗效进行了研究。方法:对象
Background: Cytomegalovirus (CMV) infection has been implicated in a number of complications after heart transplantation. A recent study suggested that children with positive CMV serology (CMV+) before transplantation are at increased risk of developing coronary allograft vasculopathy (CAV) and death when compared with CMV- recipients. We analyzed data from the Pediatric Heart Transplant Study Group to determine the impact of recipient CMV status and CMV mismatching on outcome. In addition, the use and efficacy of CMV prophylaxis were studied.Methods: Subjects