MO-C-BRCD-02: Physics of Cancer Cell Migration.
MO-C-BRCD-02: Physics of Cancer Cell Migration.
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MO-C-BRCD-02：癌细胞迁移物理学。
DOI：
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发表时间：
2012
期刊：
影响因子：
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通讯作者：
D. Wirtz
中科院分区：
文献类型：
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作者：
D. Wirtz
多年来，二维（2D）体外培养系统为研究细胞粘附和迁移提供了一个可控的、通用的环境，这两种相互关联的细胞功能对癌症转移至关重要。然而，在生理上更相关的三维基质中嵌入的细胞中，黏附蛋白的组织和功能在质量和功能上与传统的二维平面基质上的组织和功能不同。在三维交联的纤维性胶原基质中，细胞迁移和突出活动仍然受到局灶黏着蛋白的调节，如pl30Cas、FAK、Zyxin、Vinculin、Talin和VASP，但与二维情况不同。本演讲将描述肿瘤中基于黏附蛋白的细胞功能依赖于微环境维度的意义。我们将讨论这项工作在癌症转移中的意义。
Two-dimensional (2D) in vitro culture systems have for a number of years provided a controlled and versatile environment for the study of cell adhesion and migration, two interrelated cell functions critical to cancer metastasis. However, the organization and functions of focal adhesion proteins in cells embedded in physiologically more relevant 3D matrices is qualitatively and functionally different from their organization and functions on conventional 2D planar substrates. In a 3D, crosslinked, fibrillar collagen matrix, cell migration and protrusion activity are still regulated by focal adhesion proteins, such as pl30Cas, FAK, Zyxin, Vinculin, Talin, and VASP, but differently from the 2D case. This talk will describe the implications of the dependence of focal adhesion rotein-based cellular functions on microenvironmental dimensionality in cancer. We will discuss the implications of this work in cancer metastasis.