Skeletal muscle response to short endurance training in heart transplant recipients
Skeletal muscle response to short endurance training in heart transplant recipients
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DOI：
10.1016/s0735-1097(98)00227-7
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发表时间：
1998-08-01
影响因子：
24
通讯作者：
Lonsdorfer, J
中科院分区：
文献类型：
--
作者：
Lampert, E;Mettauer, B;Lonsdorfer, J
目标。我们试图研究耐力训练对心脏移植受者 (HTR) 和年龄匹配的对照受试者 (C) 骨骼肌超微结构特征的影响。背景。去适应是导致 HTR 运动能力外周限制的因素之一，训练已被证明是有益的。方法。在耐力训练计划之前和之后 6 周，对 12 名 HTR 和 7 名年龄匹配的 C 进行了股外侧肌活检（通过超微结构形态测定法分析）和股四头肌横截面积（通过计算机断层扫描 (CT) 评估）。最大摄氧量（O-2 点上的峰值 (V)）通过增量运动测试确定。此外，在 4 个 HTR 的 6 周对照期之前和之后进行了肌肉活检，以检查自发改善情况。结果。与 O-2 点相比，训练导致峰值 (V) 类似增加（HTR 增加 11%，C 增加 8.5%）、通气阈值（HTR 增加 23%，C 增加 32%）和总耐力工作（HTR 增加 54%，C 增加 31%）。总线粒体体积密度显着增加（HTR 中 26%，C 中 33%），其中肌膜下线粒体体积密度显着增加（HTR 中 74%，C 中 70%）。仅 C 中的毛细管/纤维比率就增加了 19%。在未经训练的组中，没有任何结构标记被自发修改。结论。六周的 HTR 和 C 耐力训练也带来了有氧工作能力的类似改善。然而，HTR 中减少的肌肉毛细血管网络在训练后仍未改变。免疫抑制治疗可能是造成这些患者正常线粒体含量与毛细血管供应减少之间差异的原因。 (C) 1998 年由美国心脏病学会发布。
Objectives. We sought to examine the effects of endurance training on the ultrastructural characteristics of skeletal muscle in heart transplant recipients (HTRs) and age-matched control subjects (C).Background. Deconditioning is one of the factors involved in the peripheral limitation of exercise capacity of HTRs, and training has proven to be beneficial.Methods. Biopsies of the vastus lateralis muscle, analyzed by ultrastructural morphometry, and quadriceps muscle cross-sectional area, assessed by computed tomography (CT), were performed in 12 HTRs and 7 age-matched C before and 6 weeks after an endurance training program. Maximal oxygen uptake (peak (V) over dot O-2,) was determined by an incremental exercise test. Additionally muscle biopsies were performed before and after a 6-week control period in four HTRs to check for spontaneous improvement.Results. Training resulted in similar increases in peak (V) over dot O-2, (11% in HTRs, 8.5% in C), ventilatory threshold (23% in HTRs, 32% in C) and total endurance work (54% in HTRs, 31% in C). Volume density of total mitochondria increased significantly (26% in HTRs, 33% in C) with a predominant increase of subsarcolemmal mitochondrial volume density (74% in HTRs, 70% in C). The capillary/fiber ratio increased by 19% in C only. In the nontrained group, none of the structural markers was spontaneously modified.Conclusions. Six weeks of endurance training in HTRs and C led to similar improvements of aerobic work capacity. However, the decreased muscular capillary network in HTRs remained unchanged with training. Immunosuppressive therapy might be responsible for the discrepancy between the normal mitochondrial content and the reduced capillary supply of these patients. (C) 1998 by the American College of Cardiology.