Prenylated xanthones as potential antiplasmodial substances
Prenylated xanthones as potential antiplasmodial substances
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DOI：
10.1055/s-2006-947190
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发表时间：
2006-08-01
期刊：
影响因子：
2.7
通讯作者：
Taylor, Walter C.
中科院分区：
文献类型：
--
作者：
Mahabusarakam, Wilawan;Kuaha, Kunnika;Taylor, Walter C.
研究了山竹果中主要的氧杂蒽酮化合物Mangostin及其衍生物的体外抗恶性疟原虫活性。Mangostin本身表现出中等的活性，但异戊烯化的氧杂蒽酮含有烷氨基官能团表现出相当有效的抗疟原虫活性。提出了一些构效关系。
Mangostin, the major xanthone of Garcinia mangostana, and a series of synthetic derivatives were investigated for their in vitro antiplasmodial activity against Plasmodium falciparum. Mangostin itself showed moderate activity, but prenylated xanthones containing alkylamino functional groups exhibited quite potent antiplasmodial activity. Some structure-activity relationships are proposed.