Recent Advances of Applying Boron‐Reagents in Asymmetric Total Syntheses of Natural Products and Bio‐Active Molecules
Recent Advances of Applying Boron‐Reagents in Asymmetric Total Syntheses of Natural Products and Bio‐Active Molecules
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DOI：
10.1002/adsc.202000413
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发表时间：
2020-07
影响因子：
5.4
通讯作者：
S. J. Kalita;Feng Cheng;Yiyong Huang
中科院分区：
文献类型：
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作者：
S. J. Kalita;Feng Cheng;Yiyong Huang
硼试剂是有机合成中非常有用的工具，在不对称方法学的发展中得到了广泛的探索。在过去的十年里，人们对它们在不对称全合成中的应用产生了极大的兴趣。几种合成策略，如金属转移策略，硼酸酯配体交换策略，刘易斯碱和布朗斯特酸活化策略，以及锂化-硼化策略，为开发不对称全合成的创新合成路线提供了非常强大的平台。本文综述了2007-2019年这些合成策略在天然产物以及生物和医药相关分子的不对称全合成中的应用进展。
Boron‐reagents are very useful tools in synthetic organic chemistry and have been extensively explored in the asymmetric methodology development. The past decade has witnessed an upsurge of interest in exploring their application in the asymmetric total synthesis. Several synthetic strategies, such as the transmetalation strategy, the boronate ligand exchange strategy, the Lewis base and Brønsted acid activation strategies, and the lithiation‐borylation strategy, offered very powerful platforms for the development of innovative synthetic routes for asymmetric total synthesis. This review highlights the progress (2007–2019) of the application of these synthetic strategies in the asymmetric total synthesis of natural products, and of biologically and medicinally relevant molecules.