Isoprenoid phosphonophosphates as glycosyltransferase acceptor substrates.
Isoprenoid phosphonophosphates as glycosyltransferase acceptor substrates.
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异磷酸磷酸磷酸盐作为糖基转移酶受体底物。
DOI：
10.1021/ja500622v
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发表时间：
2014-06-18
影响因子：
15
通讯作者：
Kiessling LL
中科院分区：
文献类型：
--
作者：
Martinez Farias MA;Kincaid VA;Annamalai VR;Kiessling LL
Glycosyltransferases that act on polyprenol pyrophosphate substrates are challenging to study because their lipid-linked substrates are difficult to isolate from natural sources and arduous to synthesize. To facilitate access to glycosyl acceptors, we assembled phosphonophosphate analogues and showed these are effective substrate surrogates for GlfT1, the essential product of mycobacterial gene Rv3782. Under chemically defined conditions, the galactofuranosyltransferase GlfT1 catalyzes the formation of a tetrasaccharide sequence en route to assembly of the mycobacterial galactan.
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影响因子：
15
作者：
Pedersen, Christian Marcus;Nordstrom, Lars Ulrik;Bols, Mikael
通讯作者：
Bols, Mikael
影响因子：
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作者：
Chen, L;Men, H;Walker, S
通讯作者：
Walker, S
影响因子：
2.1
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通讯作者：
Imperiali, Barbara
影响因子：
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作者：
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通讯作者：
Kiessling, Laura L.