Quantitative organ visualization using SPECT.
Quantitative organ visualization using SPECT.
复制标题
使用 SPECT 进行定量器官可视化。
作者：
L. Kircos;J. Carey;J. Keyes
使用单光子发射计算机断层扫描（SPECT）进行定量器官可视化（QOV）。器官大小是从连续的，连续的ECT图像通过感兴趣的器官与图像边界确定使用最大方向梯度边缘寻找技术计算。使用ECT计数计算器官活动，ECT计数由方向梯度、成像系统效率和成像时间限定。使用体模研究、体内犬肝脏、脾脏、膀胱和肾脏研究以及体内人膀胱研究评价了用于执行QOV的技术。研究表明，如果器官的最小尺寸大于成像系统的FWHM，并且犬大小躯干的感兴趣器官内的总放射性超过15 nCi/cc，则可以使用该系统确定绝对器官活性和器官大小，并且总成像时间限制为小于45 min，准确度约为+/- 10%。此外，可以确定有效半衰期约为1.5小时或更长。
Quantitative organ visualization (QOV) was performed using single photon emission computed tomography (SPECT). Organ size was calculated from serial, contiguous ECT images taken through the organ of interest with image boundaries determined using a maximum directional gradient edge finding technique. Organ activity was calculated using ECT counts bounded by the directional gradient, imaging system efficiency, and imaging time. The technique used to perform QOV was evaluated using phantom studies, in vivo canine liver, spleen, bladder, and kidney studies, and in vivo human bladder studies. It was demonstrated that absolute organ activity and organ size could be determined with this system and total imaging time restricted to less than 45 min to an accuracy of about +/- 10% providing the minimum dimensions of the organ are greater than the FWHM of the imaging system and the total radioactivity within the organ of interest exceeds 15 nCi/cc for dog-sized torsos. In addition, effective half-lives of approximately 1.5 hr or greater could be determined.