PPARγ in Bacterial Infections: A Friend or Foe?
PPARγ in Bacterial Infections: A Friend or Foe?
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DOI：
10.1155/2016/7963540
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发表时间：
2016
期刊：
影响因子：
2.9
通讯作者：
Reddy RC
中科院分区：
文献类型：
--
作者：
Reddy AT;Lakshmi SP;Reddy RC
过氧化物酶体增殖物激活受体γ (PPARγ)现在被认为是白细胞炎症反应和功能的重要调节剂。它的免疫调节功能已在多种情况下被研究，包括肺部和中枢神经系统的细菌感染、败血症和慢性肉芽肿病等疾病。尽管人们普遍认为，在细菌感染期间，PPARγ激活通过其抗炎和抗菌特性对宿主有益，但PPARγ激动剂也被证明会抑制宿主的免疫反应，并在某些情况下通过促进白细胞凋亡和干扰白细胞迁移和浸润而加剧感染。在这篇综述中，我们讨论了PPARγ的作用及其在细菌感染中的激活，重点是PPARγ激动剂和拮抗剂作为新的治疗方式的潜力。我们的结论是，根据宿主抗微生物防御能力和炎症反应和组织损伤的程度来调整PPARγ激动剂的剂量和时间，对于实现免疫系统的促炎和抗炎作用之间的基本平衡至关重要。
Peroxisome proliferator-activated receptor γ (PPARγ) is now recognized as an important modulator of leukocyte inflammatory responses and function. Its immunoregulatory function has been studied in a variety of contexts, including bacterial infections of the lungs and central nervous system, sepsis, and conditions such as chronic granulomatous disease. Although it is generally believed that PPARγ activation is beneficial for the host during bacterial infections via its anti-inflammatory and antibacterial properties, PPARγ agonists have also been shown to dampen the host immune response and in some cases exacerbate infection by promoting leukocyte apoptosis and interfering with leukocyte migration and infiltration. In this review we discuss the role of PPARγ and its activation during bacterial infections, with focus on the potential of PPARγ agonists and perhaps antagonists as novel therapeutic modalities. We conclude that adjustment in the dosage and timing of PPARγ agonist administration, based on the competence of host antimicrobial defenses and the extent of inflammatory response and tissue injury, is critical for achieving the essential balance between pro- and anti-inflammatory effects on the immune system.
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