THE SIGNIFICANCE OF MICRODYSGENESIA IN PRIMARY GENERALIZED EPILEPSY - AN ANSWER TO THE CONSIDERATIONS OF LYON AND GASTAUT
THE SIGNIFICANCE OF MICRODYSGENESIA IN PRIMARY GENERALIZED EPILEPSY - AN ANSWER TO THE CONSIDERATIONS OF LYON AND GASTAUT
复制标题
DOI：
10.1111/j.1528-1157.1985.tb05665.x
复制
发表时间：
1985-01-01
期刊：
影响因子：
5.6
通讯作者：
JANZ, D
中科院分区：
文献类型：
--
作者：
MEENCKE, HJ;JANZ, D
According to the proposal of Gastaut (1969) for an international classification of epilepsies, primary generalized epilepsies are characterized by a specific EEG pattern as well as by the fact that there is no morphological brain damage to be found. As a result of our study of eight cases of primary generalized epilepsy (Meencke and Janz, 1984), to which Lyon and Gastaut refer (1983, we came to the conclusion that brain damage, considered until now to be a consequence of seizures, was not seen despite frequent grand ma1 seizures. However, the brains were not without morphologically significant findings. In almost all cases there were findings in the brain which had to be characterized as “microdysgenesia” and which we interpret as being pathological and a manifestation of minimal developmental disturbances. It is because this would call into question the current definition of primary generalized epilepsy that Lyon and Gastaut ask for the pathological significance of these minor histological features, for their confirmation by controls, and for their quantification by morphometric analysis. Their questions give an opportunity for us to clarify some misunderstandings and to show the future direction of the questions that are required to arrive at new concepts.
