A wearable potentiometric sensor with integrated salt bridge for sweat chloride measurement
A wearable potentiometric sensor with integrated salt bridge for sweat chloride measurement
复制标题
DOI：
10.1016/j.snb.2017.04.129
复制
发表时间：
2017-10-01
影响因子：
8.4
通讯作者：
Searson, Peter C.
中科院分区：
文献类型：
--
作者：
Choi, Dong-Hoon;Li, Yi;Searson, Peter C.
开发可穿戴传感器来测量汗液中的生物标记物仍然是一个重大的技术挑战。在这里，我们报告了一种可穿戴的、电位式、薄膜氯化汗传感器。电位仪为汗液传感提供了一种相对简单的技术，然而，基准溶液和测试溶液之间的平衡是一个重要的误差来源。我们开发了一款集成盐桥的氯化汗传感器，最大限度地减少了平衡，并能够在更长的时间内进行稳定的测量。传感器显示出很小的浓度漂移，即使样品体积很小。在低氯离子浓度(10 Mm)和高氯离子浓度(150 Mm)下，测量误差分别小于2 mm和5 mm，覆盖了健康人和CF患者的范围。最后，在人体测试中，我们发现健康个体的汗液氯化物浓度与运动强度有关，这表明该传感器具有潜在的健康监测应用前景。(C)2017爱思唯尔B.V.保留所有权利。
The development of wearable sensors to measure biomarkers in sweat remains a major technological challenge. Here we report on a wearable, potentiometric, thin film sweat chloride sensor. Potentiometric devices provide a relatively simple technology for sweat sensing, however, equilibration between the reference and test solutions is a significant source of error. We have developed a sweat chloride sensor with integrated salt bridge that minimizes equilibration and enables stable measurements over extended periods of time. The sensor shows a very small concentration drift even with small sample volumes. The measurement variation was less than 2 mM at low chloride ion concentration (10 mM) and 5 mM at high concentration (150 mM), spanning the range for healthy individuals and CF patients. Finally, in on-body tests we show that the sweat chloride concentration in healthy individuals is dependent on exercise intensity, indicating that the sensor has a potential for a fitness monitoring applications. (C) 2017 Elsevier B.V. All rights reserved.