The effects of curcumin on depressive-like behavior in mice after lipopolysaccharide administration
The effects of curcumin on depressive-like behavior in mice after lipopolysaccharide administration
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姜黄素对脂多糖给药后小鼠抑郁样行为的影响
DOI：
10.1016/j.bbr.2014.08.018
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发表时间：
2014-11-01
影响因子：
2.7
通讯作者：
Liu, Dexiang
中科院分区：
文献类型：
--
作者：
Wang, Zhen;Zhang, Qingrui;Liu, Dexiang
目前的证据支持炎症和细胞因子水平增加与人类抑郁样症状和神经心理障碍有关。姜黄素具有抗炎、抗氧化和抗类风湿的特性。在这里，我们研究了姜黄素对脂多糖（LPS）诱导的雄性小鼠抑郁样行为和炎症的影响。单次给予LPS（0.83mg/kg，i. p.）增加小鼠强迫游泳试验（FST）和悬尾试验（TST）中的不动时间，减少蔗糖消耗量，但不影响小鼠的自发活动。用姜黄素（50 mg/kg，i. p.）连续7天逆转LPS诱导的FST、TST和蔗糖偏好试验的改变。此外，姜黄素预处理减弱LPS诱导的小胶质细胞活化和促炎细胞因子（白细胞介素-1 β和肿瘤坏死因子-α）的过度产生，以及海马和前额皮质（PFC）中诱导型一氧化氮合酶和环氧合酶-2 mRNA的水平。此外，姜黄素改善LPS诱导的NF-κ B B激活的海马和PFC。结果表明，姜黄素可能是一种有效的治疗剂LPS诱导的抑郁样行为，部分原因是其抗炎能力。(C)2014爱思唯尔有限公司版权所有。
Current evidence supports that inflammation and increased cytokine levels are associated with depression-like symptoms and neuropsychological disturbances in humans. Curcumin has anti-inflammatory, antioxidant and anti-depressant-like properties. Here, we examined the effects of curcumin on lipopolysaccharide (LPS)-induced depressive-like behavior and inflammation in male mice. A single administration of LPS (0.83 mg/kg, i.p.) increased the immobility time in the forced swimming test (FST) and tail suspension test (TST), reduced sucrose consumption without affecting spontaneous locomotor activity. Pretreatment with curcumin (50 mg/kg, i.p.) for 7 consecutive days reversed LPS-induced alterations in the FST, TST, and sucrose preference test. Moreover, pre-treatment with curcumin attenuated LPS-induced microglial activation and overproduction of pro-inflammatory cytokine (interleukin-1 beta and tumor necrosis factor-alpha), as well as the levels of inducible nitric oxide synthase and cyclooxygenase-2 mRNA in the hippocampus and prefrontal cortex (PFC). In addition, curcumin ameliorated LPS-induced NF-kappa B activation in the hippocampus and PFC. The results demonstrate that curcumin may be an effective therapeutic agent for LPS-induced depressive-like behavior, partially due to its anti-inflammatory aptitude. (C) 2014 Elsevier B.V. All rights reserved.