A rare case of human trypanosomiasis caused by Trypanosoma evansi.
A rare case of human trypanosomiasis caused by Trypanosoma evansi.
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由伊氏锥虫引起的罕见人类锥虫病。
DOI：
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发表时间：
2006
影响因子：
1.6
通讯作者：
A. Bhargava
中科院分区：
文献类型：
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作者：
RM Powar;VR Shegokar;PP Joshi;VS Dani;NS Tankhiwale;P. Truc;J. Jannin;A. Bhargava
像在非洲和南美洲看到的人类锥虫感染在印度是未知的。文献中唯一的例外是两例记录的自限性发热性疾病病例，归因于类路易氏锥虫寄生虫。我们正在报告一例来自马哈拉施特拉邦钱德拉布尔地区农村地区的不寻常锥虫病例。一名曾经从事兽医工作的成年男性农场工人，在进入本研究所之前，有5个月以来断断续续的发热史和嗜睡史。虽然常规血液和其他检查在正常范围内，但外周涂片显示大量锥虫，其形态类似于伊氏锥虫，伊氏锥虫是苏拉的病原体-一种动物锥虫病。一系列涵盖寄生虫学、血清学和分子生物学的检测证实了感染的寄生虫是T。evansi未能证明中枢神经系统（CNS）的参与，如脑脊液（CSF）中没有寄生虫所证明的，主张使用苏拉明-早期非洲锥虫病的首选药物，而没有任何CNS的参与。苏拉明治愈了我们的病人。报告该病例是因为其独特的性质，因为患者没有免疫功能低下，并显示感染了通常不会影响人类的寄生虫。
Human trypanosoma infections like the ones seen in Africa and South America are unknown in India. The only exception in literature is of two documented cases of a self-limiting febrile illness, being attributed to Trypanosoma lewisi like parasites. We are reporting an unusual case of trypanosomiasis from the rural parts of Chandrapur district in Maharashtra. An adult male farmhand who used to practice veterinary medicine also, presented with history of febrile episodes on and off since five months and drowsiness before admission to this Institute. Though routine blood and other investigations were within normal limits, the peripheral smear showed a large number of trypanosomes which morphologically resembled the species Trypanosoma evansi, the aetiological agent of surra - a form of animal trypanosomiasis. A battery of assays covering the spectrum of parasitology, serology, and molecular biology confirmed the infecting parasite to be T. evansi. Failure to demonstrate the central nervous system (CNS) involvement, as evidenced by the absence of parasite in cerebrospinal fluid (CSF) advocated the use of suramin - the drug of choice in early stage African trypanosomiasis without any CNS involvement. Suramin achieved cure in our patient. The case is being reported because of its unique nature as the patient was not immunocompromised and showed infestation with a parasite which normally does not affect human beings.