An unusual autopsy case of cytokinestorm-derived influenza-associated encephalopathy without typical histopathological findings: Autopsy case report.
An unusual autopsy case of cytokinestorm-derived influenza-associated encephalopathy without typical histopathological findings: Autopsy case report.
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细胞因子风暴衍生的流感相关脑病的不寻常尸检病例，没有典型的组织病理学发现：尸检病例报告。
DOI：
10.1097/paf.0000000000000129
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Mizuguchi M.
中科院分区：
文献类型：
--
作者：
Nara A;Nagai H;Yamaguchi R;Yoshida K;Iwase H;Mizuguchi M.
细胞因子风暴衍生的流感相关脑病是一种严重的并发症，不仅影响大脑，还影响包括心脏和肺在内的多个全身器官。每年有数百名日本儿童患有流感相关脑病。流感相关的脑病可以通过病理变化来诊断，如晚期脑水肿和星形胶质细胞投射的破坏，这被称为clasmatodendrosis。在本病例中，尽管脑中没有显著的组织病理学发现，但根据尸检发现（如脑肿胀）、病理学发现（包括弥漫性肺泡损伤）以及血清和脑脊液中白细胞介素-6浓度升高，诊断为流感相关脑病。在这种情况下，从高热到死亡的间隔时间约为7小时，可能太短，无法形成组织病理学特征。这是一例罕见的细胞因子风暴引起的流感相关脑病尸检病例，没有典型的组织病理学发现。
Cytokine storm–derived influenza–associated encephalopathy is a severe complication, affecting not only the brain but also multiple systemic organs including the heart and lungs. Hundreds of Japanese children are afflicted by influenza-associated encephalopathy every year. Influenza-associated encephalopathy can be diagnosed by pathological changes, such as advanced brain edema and disruption of astrocytic projections, which is known as clasmatodendrosis. In the present case, despite the absence of significant histopathological findings in the brain, the diagnosis of influenza-associated encephalopathy was made on the basis of autopsy findings such as brain swelling, pathological findings including diffuse alveolar damage, and increase in the concentrations of interleukin-6 in both the serum and cerebrospinal fluid. In this case, the interval from high fever to death was approximately 7 hours and may have been too short for histopathological features to develop. This is an unusual autopsy case of cytokine storm–derived influenza–associated encephalopathy without typical histopathological findings.