Reduced amygdala volumes are related to motor and cognitive signs in Huntington's disease: The IMAGE-HD study
Reduced amygdala volumes are related to motor and cognitive signs in Huntington's disease: The IMAGE-HD study
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DOI：
10.1016/j.nicl.2018.03.027
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发表时间：
2018-01-01
影响因子：
4.2
通讯作者：
Glikmann-Johnston, Yifat
中科院分区：
文献类型：
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作者：
Ahveninena, Lotta M.;Stouta, Julie C.;Glikmann-Johnston, Yifat
在亨廷顿氏病（HD）中，纹状体以外的脑区域中的神经变性的存在近来已引起关注。杏仁核就是这样一个区域，迄今为止，只有八项结构磁共振成像研究对其进行了研究，但结果不一致。这是迄今为止规模最大的MRI研究，旨在检查HD参与者的手动追踪杏仁核体积以及杏仁核体积与HD临床指标的关系。我们的研究包括35名健康对照参与者，35名症状前和36名症状性HD参与者。当比较症状前和症状性HD组与对照组时，HD组的杏仁核体积显著低于对照组，症状性HD组的杏仁核体积显著低于症状前HD组。当检查杏仁核体积与HD临床指标之间的关系时，显著较小的杏仁核体积与更差的运动和认知体征相关。对于接近疾病发作的症状前HD参与者，较小的杏仁核体积也与较高水平的焦虑症状相关。这些结果表明，杏仁核是影响症状前和症状性HD，杏仁核是相关的HD的运动症状发作前的临床资料。
In Huntington's disease (HD), the presence of neurodegeneration in brain regions other than the striatum has been recently gaining attention. The amygdala is one such area, which has been investigated in only eight structural magnetic resonance imaging studies to date, but with inconsistent findings. This is the largest MRI study to date examining manually traced amygdala volumes in HD participants and the relationship of amygdala volumes to clinical measures of HD. Our study included 35 healthy control participants, and groups of 35 pre-symptomatic, and 36 symptomatic HD participants. When comparing the pre-symptomatic and symptomatic HD groups together against the control group, amygdala volumes were significantly lower in HD than controls and in symptomatic HD than pre-symptomatic HD. When examining relationships between amygdala volumes and clinical measures of HD, significantly smaller amygdala volumes were associated with worse motor and cognitive signs. For pre-symptomatic HD participants who were close to disease onset, smaller amygdala volumes were also associated with higher levels of anxiety symptoms. These findings suggest that the amygdala is affected in pre-symptomatic and symptomatic HD, and that the amygdala is related to the clinical profile of HD before onset of motor symptoms.