Norwalk virus infection and disease is associated with ABO histo-blood group type
Norwalk virus infection and disease is associated with ABO histo-blood group type
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DOI：
10.1086/339883
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发表时间：
2002-05-01
影响因子：
6.4
通讯作者：
Estes, MK
中科院分区：
文献类型：
--
作者：
Hutson, AM;Atmar, RL;Estes, MK
有些人对诺沃克病毒（NV）感染具有抵抗力；然而，导致 NV 感染抵抗或易感的因素尚未确定。本研究调查了一个人的 ABO 组织血型类型与临床攻击后 NV 感染和症状性疾病的风险之间的关系。 ABO 表型是通过使用参加 NV 挑战研究的志愿者的血清样本（n = 51）来鉴定的。具有 O 表型的个体更有可能感染 NV（比值比 [OR]，11.8；95% 置信区间 [CI]，1.3-103），而具有 B 组织血型抗原的个体感染风险（OR，0.096；95% CI，0.16-0.56）和症状性疾病（OR，0；95% CI， 0-0.999）。这是第一份证明遗传因素与 NV 感染和症状性疾病风险之间存在关联的报告。
Some people are resistant to Norwalk virus (NV) infection; however, the factor(s) responsible for resistance or susceptibility to NV infection has not been identified. This study investigated the relationship between a person's ABO histo-blood group type and the risk of NV infection and symptomatic disease after clinical challenge. ABO phenotypes were identified by using serum samples from volunteers who participated in an NV challenge study (n = 51). Individuals with an O phenotype were more likely to be infected with NV (odds ratio [OR], 11.8; 95% confidence interval [CI], 1.3-103), whereas persons with a B histo-blood group antigen had decreased risk of infection (OR, 0.096; 95% CI, 0.16-0.56) and symptomatic disease (OR, 0; 95% CI, 0-0.999). This is the first report demonstrating an association between a genetic factor and the risk of NV infection and symptomatic disease.