Polyradiculoneuropathy induced by immune checkpoint inhibitors: a case series and review of the literature
Polyradiculoneuropathy induced by immune checkpoint inhibitors: a case series and review of the literature
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免疫检查点抑制剂诱发的多发性神经根神经病：病例系列及文献综述
DOI：
10.1007/s00415-020-10213-x
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发表时间：
2020
影响因子：
6
通讯作者：
Suzuki Shigeaki
中科院分区：
文献类型：
--
作者：
Okada Kensuke;Seki Morinobu;Yaguchi Hiroshi;Sakuta Kenichi;Mukai Taiji;Yamada Satoshi;Oki Koichi;Nakahara Jin;Suzuki Shigeaki
目的探讨免疫检查点抑制剂(ICIS)所致多发性神经根神经病的临床特点。方法回顾分析2017年1月至2019年12月三家医院神经内科收治的神经免疫相关不良事件(IrAEs)住院患者的临床资料。我们还复习了以往ICI治疗所致多发性神经根神经病的病例报道。我们全面回顾了我们的4名患者和32例先前的病例报告。男28例，女8例，平均发病年龄61岁。27例患者接受ICI单一治疗，9例患者联合ICIS治疗。除2例患者外，其余患者均出现肢体无力，呈对称性，主要位于腿部，而不是手臂。7例有延髓受累。实验室发现电生理检查显示脱髓鞘，脑脊液中淋巴细胞蛋白升高。疾病严重程度根据休斯功能评分进行排名；17名患者的病情为4级或以上。糖皮质激素和静脉注射甲基强的松龙治疗效果良好。静脉注射免疫球蛋白也与类固醇联合使用。7例死亡，包括4例机械通气患者。结论ICIS所致的多发性神经根神经病具有明显的神经性irAEs亚型，需要早期发现。
ObjectiveThe purpose of the present study is to report the clinical characteristics of polyradiculoneuropathy induced by immune checkpoint inhibitors (ICIs).MethodsWe retrospectively reviewed lists of all inpatients with neurological immune-related adverse events (irAEs) treated at the neurology departments of three hospitals in January 2017 and December 2019. We also performed a review of the previous case reports with polyradiculoneuropathy induced by ICI therapy.ResultsWe had 4 patients with polyradiculoneuropathy following ICI therapy. We comprehensively reviewed our 4 patients and 32 previous case reports. There were 28 men and 8 women with a mean onset age of 61 years. ICI monotherapy was performed in 27 patients, whereas the combination of ICIs was administered in 9 patients. All patients except 2 showed limb weakness, which was observed symmetrically and predominantly in the legs rather than the arms. Bulbar involvement was observed in 7 patients. The laboratory findings were demyelination in electrophysiological studies and elevated protein with lymphocytes in the cerebrospinal fluid. Disease severity was ranked on the Hughes functional scale; 17 patients were grade 4 or greater. The treatment responses to corticosteroid and intravenous methylprednisolone were favorable. Intravenous immunoglobulin was also used in combination with steroids. Seven patients died, including 4 who on mechanical ventilation.ConclusionPolyradiculoneuropathy induced by ICIs has a distinct subset of neurological irAEs and requires early recognition.
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与纳武利尤单抗相关的吉兰-巴利综合征：尿路上皮癌患者的病例报告及文献回顾
影响因子：
3.2
作者：
A. Kyriazoglou;M. Liontos;C. Papadopoulos;Afroditi Bilali;E. Kostouros;S. Pagoni;K. Doumas;M. Dimopoulos;A. Bamias
通讯作者：
A. Bamias
黑色素瘤患者继发于免疫检查点抑制剂的慢性炎症性脱髓鞘性多发性神经根神经病。
影响因子：
1.4
作者：
Akshita S Patel;R. Snook;A. Sehdev
通讯作者：
A. Sehdev
血浆置换、静脉注射免疫球蛋白和联合治疗吉兰-巴利综合征的随机试验
DOI：
--
发表时间：
1997
期刊：
影响因子：
--
作者：
R. Hughes;A. Swan;Cornblath;H. Hartung;Bril;T. Feasby;A. Hahn;A. Ropper;A. Steck;K. Toyka;J. Vallat;A. Asbury;J. Newsom;S. Button;R. Hohlfield;R. Voltz;B. Lecky;J. Winer;J. Rees;M. Donaghy;I. Dehaene;M. Marchau;M. Zandijcke;M. D’hooghe;W. Hacke;P. Newman;R. Shakir;P. Tilley;B. Khatri;J. Kumar;S. Sundrani;H. Willison;H. Katifi;C. Wiles;G. Hamann;S. Merkelbach;J. Stewart;L. Sales;M. Alves;I. Conceição;I. Pye;W. Robberecht;E. Peeters;J. Aasly;P. Fuhr;A. Tichelli;C. Sindic;P. Vandenbergh;F. Franck;D. Dive;G. Cavaletti;P. Santoro;T. Feasby;D. Miller;R. Howard;J. O'riordan;C. Chalk;T. Ben;J. Goldstein;M. Orshoven;J. Caekebeke;E. Schmedding;I. Ferguson;G. Stoll;R. Will;J. Pollard
通讯作者：
J. Pollard
影响因子：
10.9
作者：
Cafuir L;Lawson D;Desai N;Kesner V;Voloschin A
通讯作者：
Voloschin A
影响因子：
9.9
作者：
Dubey, Divyanshu;David, William S.;Guidon, Amanda C.
通讯作者：
Guidon, Amanda C.