Complex genetic architecture of three-dimensional craniofacial shape variation in domestic pigeons.
Complex genetic architecture of three-dimensional craniofacial shape variation in domestic pigeons.
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DOI：
10.1111/ede.12395
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发表时间：
2021-11
影响因子：
2.9
通讯作者：
Shapiro, Michael D.
中科院分区：
文献类型：
--
作者：
Boer, Elena F.;Maclary, Emily T.;Shapiro, Michael D.
破译脊椎动物颅面变异的遗传基础是一个长期存在的生物学问题，在进化、发育和人类病理学方面具有广泛的意义。颅面多样化最令人惊叹的例子之一是鸟类的适应性辐射，其中喙在其生活史的几乎各个方面都发挥着重要作用。家鸽（Columba livia）提供了一个特殊的机会，研究颅面变异的遗传基础，因为其独特的平衡实验的可及性和非凡的表型多样性在一个单一的物种。我们使用传统的和几何形态测量来量化来自直喙博美犬Pouter和弯喙Scandaroon鸽品种的F2实验室杂交的颅面变化。使用全基因组数量性状基因座扫描和多基因座建模的组合，我们确定了一组与颅面骨骼中复杂形状变化相关的遗传基因座，包括喙形状，脑壳形状和下颌骨形状。其中一些基因座控制着不同结构之间的协调变化，而另一些基因座则解释了特定头骨和颌骨区域大小和形状的变化。我们发现，在家鸽中，三维颅面形态的基础是独立和耦合遗传效应的复杂混合。鸟类是脊椎动物中头骨和颌骨多样化的最突出的例子之一。家鸽头骨和颌骨形状的特殊多样性为研究脊椎动物颅面形态的遗传结构提供了极好的机会。我们使用了几何形态测量学和数量性状基因座（QTL）定位相结合，以测量头骨和颌骨形状的变化，家鸽，并确定了一组与三维形状的变化，包括喙曲率的遗传位点。我们的研究结果为鸽子头骨和下颌形状的复杂遗传基础提供了证据。
Deciphering the genetic basis of vertebrate craniofacial variation is a longstanding biological problem with broad implications in evolution, development, and human pathology. One of the most stunning examples of craniofacial diversification is the adaptive radiation of birds, in which the beak serves essential roles in virtually every aspect of their life histories. The domestic pigeon (Columba livia) provides an exceptional opportunity to study the genetic underpinnings of craniofacial variation because of its unique balance of experimental accessibility and extraordinary phenotypic diversity within a single species. We used traditional and geometric morphometrics to quantify craniofacial variation in an F2 laboratory cross derived from the straight‐beaked Pomeranian Pouter and curved‐beak Scandaroon pigeon breeds. Using a combination of genome‐wide quantitative trait locus scans and multi‐locus modeling, we identified a set of genetic loci associated with complex shape variation in the craniofacial skeleton, including beak shape, braincase shape, and mandible shape. Some of these loci control coordinated changes between different structures, while others explain variation in the size and shape of specific skull and jaw regions. We find that in domestic pigeons, a complex blend of both independent and coupled genetic effects underlie three‐dimensional craniofacial morphology. Birds represent one of the most striking examples of skull and jaw diversification among vertebrates. The exceptional diversity of skull and jaw shapes within domestic pigeons provides an outstanding opportunity to study the genetic architecture of vertebrate craniofacial morphology. We used a combination of geometric morphometrics and quantitative trait loci (QTL) mapping to measure skull and jaw shape variation in domestic pigeons and identified a set of genetic loci associated with 3D shape variation, including beak curvature. Our results provide evidence for a complex genetic basis for skull and jaw shape in pigeons.
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影响因子：
2.7
作者：
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通讯作者：
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DOI：
10.1002/jez.b.22641
发表时间：
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影响因子：
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DOI：
10.1073/pnas.0911575107
发表时间：
2010-02-23
影响因子：
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