Engineering of biomimetic nanofibrous matrices for drug delivery and tissue engineering.
Engineering of biomimetic nanofibrous matrices for drug delivery and tissue engineering.
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DOI：
10.1039/c4tb01464b
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发表时间：
2014-10
期刊：
影响因子：
--
通讯作者：
Chuanglong He;W. Nie;Wei Feng
中科院分区：
文献类型：
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作者：
Chuanglong He;W. Nie;Wei Feng
仿生纳米纤维已经成为药物输送和组织工程应用的有前途的候选材料。本文综述了仿生纳米纤维作为药物载体和支架材料的制备及其应用的最新进展。首先，我们概述了三种流行的纳米纤维制备技术，包括静电纺丝、相分离和分子自组装，包括用于不同技术的主要材料和纳米纤维的表面功能化策略。此外，我们的兴趣集中在基于纳米纤维的传递策略和潜在的生长因子和其他生物活性分子的动力学，随后我们总结了这些纳米纤维基质在骨、血管和神经组织工程应用方面的最新进展。最后，讨论了相关领域的研究挑战和未来发展趋势。
Biomimetic nanofibers have emerged as promising candidates for drug delivery and tissue engineering applications. In this paper, recent advances on the fabrication and application of biomimetic nanofibers as drug carriers and scaffolding materials are reviewed. First, we delineate the three popular nanofiber fabrication techniques including electrospinning, phase separation and molecular self-assembly, covering the principal materials used for different techniques and surface functionalization strategies for nanofibers. Furthermore, we focus our interest on the nanofiber-based delivery strategies and underlying kinetics for growth factors and other bioactive molecules, following which we summarize the recent advances in the development of these nanofibrous matrices for bone, vascular and neural tissue engineering applications. Finally, research challenges and future trends in the related areas are discussed.