Lymphatics in Human Lymphatic Filariasis: In Vitro Models of Parasite-Induced Lymphatic Remodeling
Lymphatics in Human Lymphatic Filariasis: In Vitro Models of Parasite-Induced Lymphatic Remodeling
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DOI：
10.1089/lrb.2009.0022
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发表时间：
2009-01-01
影响因子：
1.4
通讯作者：
Nutman, Thomas B.
中科院分区：
文献类型：
--
作者：
Bennuru, Sasisekhar;Nutman, Thomas B.
淋巴丝虫病的特征是淋巴管功能障碍，可导致严重的（通常）不可逆的水肿和象皮肿。该领域数十年的研究表明，成虫寄生虫在寄生虫体内的建立引发了一系列事件，最终导致组织瘢痕形成和纤维化。在这篇小综述中，我们重点讨论了寄生虫诱导的淋巴管扩张的机制，这表明寄生虫诱导的淋巴管重塑和淋巴管生成可能是发展慢性和不可逆丝虫病的前奏。
Lymphatic filariasis characterized by the dysfunction of the lymphatics can lead to severe (and often) irreversible lymphedema and elephantiasis. Decades of research in the field shows that the establishment of the adult parasites in the lymphatics triggers a cascade of events that ultimately results in tissue scarring and fibrosis. In this minireview, we focus on the studies addressing the mechanisms underlying the parasite-induced lymphatic dilatation that suggests parasite-induced lymphatic remodeling and lymphangiogenesis may be the prelude towards developing chronic and irreversible filarial pathology.