Synthesis of the repeating unit of the O-specific polysaccharide of Shigella sonnei and quantitation of its serologic activity
Synthesis of the repeating unit of the O-specific polysaccharide of Shigella sonnei and quantitation of its serologic activity
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DOI：
10.1016/s0960-894x(99)00585-5
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发表时间：
2000-01-03
影响因子：
2.7
通讯作者：
Pozsgay, V
中科院分区：
文献类型：
--
作者：
Tóth, A;Medgyes, A;Pozsgay, V
描述了两性离子二糖2的化学合成，其对应于革兰氏阴性人类病原体宋内志贺菌的O-特异性多糖（1）的重复单元。使用抗S的超免疫兔血清进行被动溶血抑制试验。Sonnei表明二糖2的血清学活性比其组分单糖的血清学活性高近2- 3倍。2的NMR数据支持所提出的O-特异性多糖的结构。(C)1999爱思唯尔科技有限公司。保留所有权利。
The chemical synthesis of the zwitterionic disaccharide 2 is described that corresponds to the repeating unit of the O-specific polysaccharide (1) of the Gram-negative human pathogen Shigella sonnei. Passive hemolysis inhibition tests using a hyperimmune rabbit serum raised against S. sonnei showed that the serologic activity of the disaccharide 2 is nearly 2- to 3-fold higher than those of its component monosaccharides. NMR data of 2 are in support of the proposed structure of the O-specific polysaccharide. (C) 1999 Elsevier Science Ltd. All rights reserved.