Influence of prostaglandins on sodium transport of isolated medullary nephron segments.
Influence of prostaglandins on sodium transport of isolated medullary nephron segments.
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前列腺素对离体髓质肾单位节段钠转运的影响。
DOI：
10.1152/ajprenal.1977.232.4.f383
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发表时间：
1977
期刊：
影响因子：
--
通讯作者：
W. Trizna
中科院分区：
文献类型：
--
作者：
L. Fine;W. Trizna
通过将前列腺素PGE2、PGF2alpha和PGA2添加到离体兔肾厚升肾和收集小管的小管周围和管腔表面，研究了位于肾髓质的前列腺素（PG）通过直接管状作用影响肾钠排泄的可能性。高浓度（2.5 × 10(-4) M）和低浓度(10 （-10)M, 10(-7) M）的前列腺素对这些节段的上皮电位差和净钠通量没有影响。用吲哚美辛预处理动物对实验结果无影响。在体内，当PGE2和PGF2alpha直接输注到一条肾动脉时，都引起钠尿，而PGA2对钠排泄没有影响。前列腺素抑制剂吲哚美辛、甲氯芬酯和RO 20-5720同样对所研究的肾单元段的钠转运没有直接影响。由此可见，前列腺素和前列腺素抑制剂对钠在体内肾脏排泄的影响不是通过肾小管直接介导的。
The possibility that prostaglandins (PG) located in the renal medulla may influence renal excretion of sodium by a direct tubular action was examined by the addition of prostaglandins PGE2, PGF2alpha, and PGA2 to the peritubular and luminal surfaces of isolated perfused medullary thick ascending lumbs and collecting tubules from rabbit kidneys. The prostaglandins at both high (2.5 x 10(-4) M) and low (10 (-10) M, 10 (-7) M) concentrations had no effect on transepithelial potential difference and net sodium flux across these segments. Pretreatment of the animals with indomethacin did not influence the results. In vivo, both PGE2 and PGF2alpha, caused a natriuresis when infused directly into one renal artery, whereas PGA2 had no effect on sodium excretion. The prostaglandin inhibitors indomethacin, meclofenamate, and RO 20-5720 similarly had no direct effect on sodium transport in the nephron segments studied. It is concluded that the previously observed influence of prostaglandins and prostaglandin inhibitors on renal excretion of sodium in vivo are not mediated by a direct tubular action.