FACTORS AFFECTING VOLUNTARY MORPHINE INTAKE IN SELF-MAINTAINED ADDICTED RATS
FACTORS AFFECTING VOLUNTARY MORPHINE INTAKE IN SELF-MAINTAINED ADDICTED RATS
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DOI：
10.1007/bf00413156
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发表时间：
1964-01-01
期刊：
影响因子：
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通讯作者：
COLLINS, RJ
中科院分区：
文献类型：
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作者：
WEEKS, JR;COLLINS, RJ
通过植入慢性静脉插管，给大鼠安装一个相对自由活动的装置，并通过按压杠杆使大鼠随意获得吗啡注射，制备了自我维持的吗啡成瘾大鼠。研究了影响吗啡自愿摄入的三个因素。使用连续强化计划，逐渐减少吗啡剂量的大小导致每天更多的剂量。补偿是不完全的，因为每日吗啡总摄入量减少了。逐渐增加一个固定的定量强化计划，直到大约FR-75，导致大鼠继续对杠杆产生反应，直到获得剂量。FR-75以上的反应是间歇性的，每日吗啡随着剂量间隔的增加而减少。连续静脉输注第二种药物，在FR-10时自愿获得吗啡，导致在输注吗啡本身、可待因和哌嗪后吗啡摄入量减少。纳洛啡输注增加吗啡摄入量。注射效果随注射速度的不同而不同。
Self-maintained morphine addicted rats were prepared by implanting chronic venous cannulas and fitting the rats with a device permitting relatively free movement and also enabling them to obtain morphine injections at will by pressing a lever. Three factors modifying voluntary morphine intake were studied. Using a continuous reinforcement schedule, progressively decreasing the size of the morphine dose led to a greater number of doses daily. Compensation was incomplete in that the total daily morphine intake decreased. Progressively increasing a fixed ration reinforcement schedule up to about FR-75, caused rats to continue responding on the lever until the dose was obtained. Above FR-75 responding became intermittent and daily morphine decreased as the time interval between doses increased. Continuous intravenous infusion of a second drug, leaving voluntary access to morphine at FR-10, led to decreased morphine intake following infusion of morphine itself, codeine and meperidlne. Nalorphine infusion increased morphine intake. Effectiveness of infusions varied with the infusion rate.