Syncopal attack alters the burst properties of muscle sympathetic nerve activity in humans
Syncopal attack alters the burst properties of muscle sympathetic nerve activity in humans
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DOI：
10.1016/s1566-0702(01)00362-9
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发表时间：
2002-01-10
影响因子：
2.7
通讯作者：
Suzumura, A
中科院分区：
文献类型：
--
作者：
Iwase, S;Mano, T;Suzumura, A
本研究旨在探讨在低血压发作期间，微神经造影记录的肌肉交感神经活动（MSNA）的性质是否发生改变。回顾性研究了74名参与倾斜研究的受试者，其中6名受试者偶然诱发血管抑滥性晕厥。将MSNA活动与皮肤交感神经活动区分开来的具体特征是：(1)有节奏的脉冲同步爆发放电，(2)持续时间约为150-300 ms，(3)在晕厥发作期间对唤醒刺激没有反应。这6名受试者在晕厥发作时表现为：(1)心电r波中MSNA峰反射潜伏期分散，(2)爆发持续时间较清醒状态延长2 ~ 5倍，(3)对唤醒刺激有反应。孤立束核近端的中央交感神经截击受到抑制，压力感受器输入减少，这可能是由于MSNA特征丧失所致。(C) 2002 Elsevier Science B.V.版权所有
This study aimed at examining whether the properties of microneurographically recorded muscle sympathetic nerve activity (MSNA) were altered during hypotensive attacks. A retrospective study was performed on 74 subjects who participated in tilt studies when vasodepressive syncope was induced incidentally in six subjects. The specific features of MSNA that distinguish this activity from skin sympathetic nerve activity are (1) rhythmic pulse synchronous burst discharge, (2) a duration of approximately 150-300 ms, and (3) no response to arousal stimuli were abolished during the syncopal attack. The altered features observed during the syncopal attack in these six subjects were (1) scattered reflex latencies of MSNA peak from the ECG R-wave, (2) elongated burst duration twice to five times as long as that in conscious state, and (3) response to arousal stimuli. The reduced input from the baroreceptors due to suppression on the central sympathetic volley proximal to the nucleus tractus solitarius might be attributed to the lost features characteristic of MSNA. (C) 2002 Elsevier Science B.V. All rights reserved.