A comprehensive review of the functions of YB-1 in cancer stemness, metastasis and drug resistance.

A comprehensive review of the functions of YB-1 in cancer stemness, metastasis and drug resistance.
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YB-1在肿瘤发生、转移及耐药中的作用综述

DOI:
10.1016/j.cellsig.2021.110073
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发表时间:
2021-09
影响因子:
4.8
通讯作者:
Sossey-Alaoui K
Sossey-Alaoui K
中科院分区:
生物学2区
文献类型:
--
作者:
Alkrekshi A;Wang W;Rana PS;Markovic V;Sossey-Alaoui K

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Y Box结合蛋白1 (YB-1)是高度保守的冷休克域蛋白家族的成员,在细胞质和细胞核内都具有多功能特性。YB-1还参与多种细胞功能,包括转录调节、mRNA稳定性和剪接。最近的研究表明,YB-1与几种肿瘤类型的恶性表型调节有关。在这篇综述文章中,我们提供了深入和广泛的文献有关YB-1的多种生理功能的回顾。我们还将回顾YB-1在各种恶性肿瘤的发生、进展、转移和耐药中的作用,重点介绍近十年发表的文献。方法包括查询PubMed、Embase和谷歌Scholar数据库获取Y box结合蛋白1、YB-1、YBX1和Y-box-1。
The Y Box binding protein 1 (YB-1) is a member of the highly conserved Cold Shock Domain protein family with multifunctional properties both in the cytoplasm and inside the nucleus. YB-1 is also involved in various cellular functions, including regulation of transcription, mRNA stability, and splicing. Recent studies have associated YB-1 with the regulation of the malignant phenotypes in several tumor types. In this review article, we provide an in-depth and expansive review of the literature pertaining to the multiple physiological functions of YB-1. We will also review the role of YB-1 in cancer development, progression, metastasis, and drug resistance in various malignancies, with more weight on literature published in the last decade. The methodology included querying databases PubMed, Embase, and Google Scholar for Y box binding protein 1, YB-1, YBX1, and Y-box-1.
DOI: 10.1038/nrc.2017.99
发表时间: 2018-01
期刊: Nature reviews. Cancer
影响因子: --
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