Correcting CT misregistration in data-driven gated (DDG) PET with PET self-gating and deformable image registration.
Correcting CT misregistration in data-driven gated (DDG) PET with PET self-gating and deformable image registration.
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通过 PET 自门控和可变形图像配准，纠正数据驱动门控 (DDG) PET 中的 CT 重合失调。
DOI：
10.1002/mp.16958
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发表时间：
2024
期刊：
影响因子：
3.8
通讯作者：
Pan,Tinsu
中科院分区：
文献类型：
--
作者：
Sun,Peng;Thomas,MAllan;Luo,Dershan;Pan,Tinsu
背景CT和PET数据之间的配准错误可能导致全身PET/CT成像中功能摄取的错误定位和不准确定量。当在用于PET数据衰减校正的自由呼吸螺旋CT（FB CT）期间发生异常吸气时，该问题会加剧。在数据驱动门控（DDG）PET中，选择用于重建的数据通常来自呼吸周期的呼气末（EE）阶段，目的本研究的目的是开发一种基于变形图像配准（Deformable Image Registration，EMT）的呼吸运动模型，以改善配准错误的FB CT和PET之间的配准和定量。本研究分析了48个配准错误区域的病变CT扫描。吸气末（EI）和EE PET数据分别来自呼吸周期的−10%至15%和30%至80%。使用ESTA来估计从PET数据的EE到EI相位的运动模型。然后，该模型用于在EE和EI之间运动幅度高达四倍的任何相位生成PET图像，以与配准错误的FB CT相关联。一旦确定了FB CT的匹配相位，FB CT就在EE相位（ECOCT）变形为伪CT。结果DDG PET/FB CT和DDG PET/FDCT在AC和DDG PET/FDCT的定位方面，均能显著提高SUV的检出率（P< 0.01），中位数从26.7%提高到42.4%。这种新方法对距离膈肌近端≤3 cm的病变最有效（p< 0.001），但随着距离的增加，疗效降低。当FB CT与DDG PET严重配准错误（>3 cm）时，DDG PET/FDCT优于单独的DDG PET/FB CT（p< 0.05）。即使患者在PET/CT扫描期间表现出不同的呼吸模式，DDG PET/FDCT仍然优于DDG PET/FB CT的效率（p< 0.01）。虽然DDG PET/CT的性能无法与DDG PET/CT的地面实况相匹配（42.4%与53.6%，p < 0.01），达到其定量的84%，显示出良好的一致性和强的总体相关性（回归系数为0.94，p < 0.0001）。在某些情况下，解剖失真和模糊，和配准误差观察到在双螺旋CT，渲染它仍然无法纠正不准确的定位附近的边界的两个organs.ConclusionsBased上的运动模型来自门控PET数据，双螺旋CT可以显着提高定量和定位的DDG PET。这种方法可以实现DDG PET/CT建立的地面真实值的约84%的性能水平。这些结果表明，自门控PET和SPECT CT可以为DDG PET和FB CT提供替代临床解决方案，用于定量，而无需额外的电影CT成像。由于解剖结构的一些失真和模糊以及配准错误，HRCT有时劣于DDG CT。
BackgroundMisregistration between CT and PET data can result in mis‐localization and inaccurate quantification of functional uptake in whole body PET/CT imaging. This problem is exacerbated when an abnormal inspiration occurs during the free‐breathing helical CT (FB CT) used for attenuation correction of PET data. In data‐driven gated (DDG) PET, the data selected for reconstruction is typically derived from the end‐expiration (EE) phase of the breathing cycle, making this potential issue worse.PurposeThe objective of this study is to develop a deformable image registration (DIR)‐based respiratory motion model to improve the registration and quantification between misregistered FB CT and PET.MethodsTwenty‐two whole‐body18F‐FDG PET/CT scans encompassing 48 lesions in misregistered regions were analyzed in this study. End‐inspiration (EI) and EE PET data were derived from −10% to 15% and 30% to 80% of the breathing cycle, respectively. DIR was used to estimate a motion model from the EE to EI phase of the PET data. The model was then used to generate PET images at any phase of up to four times the amplitude of motion between EE and EI for correlation with the misregistered FB CT. Once a matched phase of the FB CT was determined, FB CT was deformed to a pseudo CT at the EE phase (DIR CT). DIR CT was compared with the ground truth DDG CT for AC and localization of the DDG PET.ResultsBetween DDG PET/FB CT and DDG PET/DIR CT, a significant increase in ∆%SUV was observed (p< 0.01), with median values elevating from 26.7% to 42.4%. This new method was most effective for lesions ≤3 cm proximal to the diaphragm (p< 0.001) but showed decreasing efficacy as the distance increased. When FB CT was severely misregistered with DDG PET (>3 cm), DDG PET/DIR CT outperformed DDG PET/FB CT alone (p< 0.05). Even when patients showed varied breathing patterns during the PET/CT scan, DDG PET/DIR CT still surpassed the efficiency of DDG PET/FB CT (p< 0.01). Though DDG PET/DIR CT couldn't match the performance of the DDG PET/CT ground truth (42.4% vs. 53.6%,p< 0.01), it reached 84% of its quantification, demonstrating good agreement and a strong overall correlation (regression coefficient of 0.94,p< 0.0001). In some cases, anatomical distortion and blurring, and misregistration error were observed in DIR CT, rendering it still unable to correct inaccurate localization near the boundaries of two organs.ConclusionsBased on the motion model derived from gated PET data, DIR CT can significantly improve the quantification and localization of DDG PET. This approach can achieve a performance level of about 84% of the ground truth established by DDG PET/CT. These results show that self‐gated PET and DIR CT may offer an alternative clinical solution to DDG PET and FB CT for quantification without the need for additional cine‐CT imaging. DIR CT was at times inferior to DDG CT due to some distortion and blurring of anatomy and misregistration error.
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影响因子：
2.7
作者：
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DOI：
--
发表时间：
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期刊：
International Journal of Radiation Oncology, Biology, Physics
影响因子：
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