A profile of intravenous nitroglycerin use in cardiopulmonary bypass surgery
A profile of intravenous nitroglycerin use in cardiopulmonary bypass surgery
复制标题
体外循环手术中静脉注射硝酸甘油的应用概况
DOI：
10.1007/bf03009343
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
M. Bessette
中科院分区：
文献类型：
--
作者：
G. Townsend;J. Wynands;D. Whalley;A. Cohen;M. Bessette
We studied the indications for use, time to onset of effect, approximate effective concentration and therapeutic success of commercially prepared intravenous nitroglycerin (NTG) in 50 patients undergoing cardiopulmonary bypass (CPB) surgery, Nitroglycerin was used to treat systemic or pulmonary hypertension, myocardial ischaemiaand ventricular failure. Twenty-one patients had more than one indication for NTG use. Nineteen of 22 patients with pulmonary hypertension, 12 of 13 patients with ischaemic changes, and 13 of 15 patients with ventricular failure improved during intravenous NTG administration. Hypertension during CPB was ameliorated in only six often instances. The time to onset of effect ranged from 4.1 ± 0.8 to 7.8 ± 2.8 minutes and the mean approximate effective NTG concentration varied from 1.7 ± 0.3 to 2.9 ± 0.7 μg · kg-1± min-1(doses only approximate due to our use of an infusion system which absorbs NTG). Complications from intravenous NTG administration were not seen. We conclude that this NTG preparation facilitates treatment of prebypass hypertension, pulmonary hypertension, myocardial ischaemiaand ventricular failure but is less effective for the treatment of hypertension during CPB.
