Evidence for genetic variance in resistance to tuberculosis in Great Britain and Irish Holstein-Friesian populations.
Evidence for genetic variance in resistance to tuberculosis in Great Britain and Irish Holstein-Friesian populations.
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DOI：
10.1186/1753-6561-5-s4-s15
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发表时间：
2011-06-03
期刊：
影响因子：
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通讯作者：
Woolliams JA
中科院分区：
文献类型：
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作者：
Bermingham ML;Brotherstone S;Berry DP;More SJ;Good M;Cromie AR;White IM;Higgins IM;Coffey M;Downs SH;Glass EJ;Bishop SC;Mitchell AP;Clifton-Hadley RS;Woolliams JA
在这里，我们共同总结了对牛结核病 (TB) 的主要病原体牛分枝杆菌感染抵抗力的遗传变异的科学证据，这些证据是由最近对英国 (GB) 和爱尔兰的荷斯坦-弗里斯兰奶牛群体进行的两项独立研究提供的。这些研究量化了每个国家实地和屠宰场监测控制计划的存档数据中的遗传变异。这些数据包括单一皮内比较结核菌素试验 (SICTT)、屠宰场结核病灶检查以及疾病状态实验室确认的结果。使用阈值动物模型来估计对 SICTT 和屠宰场确认的牛支原体感染的反应性的方差分量。观察到的 0/1 量表和责任量表之间的链接函数是 GB 中的互补对数对数，以及爱尔兰人口中的 logit 链接函数。根据对 SICTT 的反应判断，英国和爱尔兰人群的结核病易感性估计遗传力分别为 0.16 (0.012) 和 0.14 (0.025)。对于屠宰场或实验室感染确认，英国和爱尔兰人群的估计值分别为 0.18 (0.044) 和 0.18 (0.041)。估计值均与零显着不同，表明英国奶牛和爱尔兰荷斯坦弗里斯兰奶牛对结核病的抵抗力存在可利用的变异。流行病学分析表明，暴露变化或敏感性和特异性不完善等因素可能会导致真实值被低估。
Here, we jointly summarise scientific evidence for genetic variation in resistance to infection with Mycobacterium bovis, the primary agent of bovine tuberculosis (TB), provided by two recent and separate studies of Holstein-Friesian dairy cow populations in Great Britain (GB) and Ireland. The studies quantified genetic variation within archived data from field and abattoir surveillance control programmes within each country. These data included results from the single intradermal comparative tuberculin test (SICTT), abattoir inspection for TB lesions and laboratory confirmation of disease status. Threshold animal models were used to estimate variance components for responsiveness to the SICTT and abattoir confirmed M. bovis infection. The link functions between the observed 0/1 scale and the liability scale were the complementary log-log in the GB, and logit link function in the Irish population. The estimated heritability of susceptibility to TB, as judged by responsiveness to the SICTT, was 0.16 (0.012) and 0.14 (0.025) in the GB and Irish populations, respectively. For abattoir or laboratory confirmation of infection, estimates were 0.18 (0.044) and 0.18 (0.041) from the GB and the Irish populations, respectively. Estimates were all significantly different from zero and indicate that exploitable variation exists among GB and Irish Holstein Friesian dairy cows for resistance to TB. Epidemiological analysis suggests that factors such as variation in exposure or imperfect sensitivity and specificity would have resulted in underestimation of the true values.