Muscle-bone crosstalk and potential therapies for sarco-osteoporosis
Muscle-bone crosstalk and potential therapies for sarco-osteoporosis
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DOI：
10.1002/jcb.28946
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发表时间：
2019-09-01
影响因子：
4
通讯作者：
Shang, Peng
中科院分区：
文献类型：
--
作者：
Li, GuoBin;Zhang, Lan;Shang, Peng
肌肉-骨骼串扰的性质历来被认为是机械的，肌肉是负荷的施加者，而骨骼提供附着点。然而，这一教条受到了新概念的挑战，即骨骼和肌肉充当内分泌器官，相互影响功能。生化串扰通过肌抑制素、淫羊藿素、白介素6、白介素7、白介素15、胰岛素样生长因子1、成纤维细胞生长因子2和β-氨基异丁酸等肌肉因子以及骨源性因子如FGF23、前列腺素E-2、转化生长因子β、骨钙素和硬化素发生。除了生化和机械相互作用外，其他因素，包括衰老、昼夜节律、神经系统网络、营养摄入和外周体体也对骨-肌肉串扰有影响。在这里，我们总结目前在该领域的研究进展，这可能有助于发现潜在的治疗骨质疏松症和石棺减少的新方法，特别是当它们平行发展时。
The nature of muscle-bone crosstalk has been historically considered to be only mechanical, where the muscle is the load applier while bone provides the attachment sites. However, this dogma has been challenged with the emerging notion that bone and muscle act as secretory endocrine organs affect the function of each other. Biochemical crosstalk occurs through myokines such as myostatin, irisin, interleukin (IL)-6, IL-7, IL-15, insulin-like growth factor-1, fibroblast growth factor (FGF)-2, and beta-aminoisobutyric acid and through bone-derived factors including FGF23, prostaglandin E-2, transforming growth factor beta, osteocalcin, and sclerostin. Aside from the biochemical and mechanical interaction, additional factors including aging, circadian rhythm, nervous system network, nutrition intake, and exosomes also have effects on bone-muscle crosstalk. Here, we summarize the current research progress in the area, which may be conductive to identify potential novel therapies for the osteoporosis and sarcopenia, especially when they develop in parallel.