Electrochemical Selective Detection of Uric Acid Using a Copper-modified Carbon Electrode
Electrochemical Selective Detection of Uric Acid Using a Copper-modified Carbon Electrode
复制标题
DOI：
10.2116/analsci.27.333
复制
发表时间：
2011-03
影响因子：
1.6
通讯作者：
H. Sakamoto;R. Hatsuda;K. Miyamura;H. Shiraishi;S. Sugiyama
中科院分区：
文献类型：
--
作者：
H. Sakamoto;R. Hatsuda;K. Miyamura;H. Shiraishi;S. Sugiyama
（人）血清中的尿酸（UA）水平是多种疾病的重要指标；然而，由于UA和抗坏血酸（AA）的氧化电位非常接近，其电化学检测很困难。在这项研究中，我们开发了一种使用铜修饰碳电极的简单高效的UA检测方法。检测原理是基于Cu(II)对AA的选择性氧化，其中Cu(II)选择性地与AA反应，但不与UA反应。通过在电极表面进行这种特定反应，我们成功地区分了 UA 的氧化电位，而没有 AA 的干扰。
The uric acid (UA) level in (human) serum is an important indicator of several diseases; however, its electrochemical detection is difficult because the oxidation potentials of UA and ascorbic acid (AA) are very close. In this study, we have developed a simple and efficient UA detection method using a copper-modified carbon electrode. The detection principle is based on the selective oxidation of AA by Cu(II), wherein Cu(II) reacts selectively with AA but not with UA. By performing this specific reaction on an electrode surface, we have successfully distinguished the oxidation potential of UA without AA interference.