High expression of Jun activation domain-binding protein 1 (Jab1) is a strong prognostic marker in oral squamous cell carcinoma patients treated by UFT in combination with radiation.
High expression of Jun activation domain-binding protein 1 (Jab1) is a strong prognostic marker in oral squamous cell carcinoma patients treated by UFT in combination with radiation.
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发表时间：
2006-03
影响因子：
2
通讯作者：
K. Harada;Yuichiro Kawashima;H. Yoshida;Mitsunobu Sato
中科院分区：
文献类型：
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作者：
K. Harada;Yuichiro Kawashima;H. Yoshida;Mitsunobu Sato
p27 Kip1的低表达与包括口腔鳞状细胞癌（OSCC）在内的几种恶性肿瘤的疾病进展和不良结局相关。此外，p27 Kip1蛋白被认为是由Jun激活结构域结合蛋白1（Jab1）降解的。本研究的目的是检查Jab1表达是否可以成为接受1 M替加氟和4 M尿嘧啶（UFT）联合放射治疗的OSCC患者的有用预后因素。应用免疫组织化学方法检测了102例接受UFT联合放疗的口腔鳞癌患者活检标本中Jab1的表达。同时分析了每种表达与临床病理特征和患者生存期的关系。Jab1表达与颈淋巴结转移（p=0.0004）、疾病分期（p=0.0011）、治疗效果（p=0.0133）和患者预后（p=0.0095）之间存在显著相关性。Jab1高表达和低表达肿瘤的5年生存率分别为53.0%和80.6%，通过对数秩检验，该差异具有显著性（p=0.0053）。多变量分析显示，长期生存率降低与高水平的Jab1表达相关（p=0.0082）。这些结果表明，Jab1可能是一个有用的预后因素，在口腔鳞癌患者的UFT联合放射治疗。
Low expression of p27Kip1 is associated with disease progression and an unfavorable outcome in several malignancies, including oral squamous cell carcinoma (OSCC). In addition, the p27Kip1 protein is thought to be degraded by the Jun activation domain-binding protein 1 (Jab1). The purpose of this study was to examine whether Jab1 expression can be a useful prognostic factor in OSCC patients treated by 1 M Tegafur and 4 M uracil (UFT) in combination with radiation. Jab1 expression was investigated by immunohistochemistry in biopsy samples from 102 OSCC patients who were treated by UFT in combination with radiation. The associations of each expression with the clinicopathological characteristics and patient survival were also analyzed. A significant association was found between Jab1 expression and cervical lymph node metastasis (p=0.0004), stage of disease (p=0.0011), therapeutic effect (p=0.0133) and patient outcome (p=0.0095). The 5-year survival rates of Jab1 high- and low-expression tumors were 53.0% and 80.6%, respectively and this difference was significant (p=0.0053) by the log-rank test. Multivariate analysis revealed that reduced term survival was related to high levels of Jab1 expression (p=0.0082). These results suggest that Jab1 may be a useful prognostic factor in OSCC patients treated by UFT in combination with radiation.