The plasticity and stability of regulatory T cells
The plasticity and stability of regulatory T cells
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DOI：
10.1038/nri3464
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发表时间：
2013-06-01
影响因子：
100.3
通讯作者：
Waldmann, Herman
中科院分区：
文献类型：
--
作者：
Sakaguchi, Shimon;Vignali, Dario A. A.;Waldmann, Herman
调节性 T (T-Reg) 细胞对于预防小鼠和人类致命的自身免疫至关重要。 Forkhead box P3 (FOXP3)(+) T-Reg 细胞在胸腺中产生，也由外周部位的常规 CD4(+) T 细胞产生。有人提出，FOXP3(+) T-Reg 细胞在某些炎症条件下可能变得不稳定，并可能采取更具有效应 CD4(+) T 细胞特征的表型。这些建议在该领域引起了相当大的争论，并对 T-Reg 细胞的治疗用途具有重要意义。在这篇文章中，《自然评论免疫学》询问了几位专家对 T-Reg 细胞的可塑性和稳定性的看法。
Regulatory T (T-Reg) cells are crucial for the prevention of fatal autoimmunity in mice and humans. Forkhead box P3 (FOXP3)(+) T-Reg cells are produced in the thymus and are also generated from conventional CD4(+) T cells in peripheral sites. It has been suggested that FOXP3(+) T-Reg cells might become unstable under certain inflammatory conditions and might adopt a phenotype that is more characteristic of effector CD4(+) T cells. These suggestions have caused considerable debate in the field and have important implications for the therapeutic use of T-Reg cells. In this article, Nature Reviews Immunology asks several experts for their views on the plasticity and stability of T-Reg cells.