Neurometabolic and functional connectivity basis of prosocial behavior in early adolescence
Neurometabolic and functional connectivity basis of prosocial behavior in early adolescence
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青春期早期亲社会行为的神经代谢和功能连接基础
DOI：
10.1038/s41598-018-38355-z
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发表时间：
2019
影响因子：
4.6
通讯作者：
Kasai K
中科院分区：
文献类型：
--
作者：
Okada N;Yahata N;Koshiyama D;Morita K;Sawada K;Kanata S;Fujikawa S;Sugimoto N;Toriyama R;Masaoka M;Koike S;Araki T;Kano Y;Endo K;Yamasaki S;Ando S;Nishida A;Hiraiwa-Hasegawa M;Edden R A. E.;Barker P B.;Sawa A;Kasai K
人类的亲社会行为（PB）出现在儿童期，成熟于青春期。之前的任务相关功能磁共振成像（fMRI）研究报告了内侧前额叶皮质（包括前扣带回皮质（ACC））参与青春期的社会认知。然而，青少年早期PB的神经代谢和功能连接（FC）基础尚不清楚。在这里，我们测量GABA水平的ACC和FC的一个子样本（年龄10.5-13.4岁）的一个大规模的人口为基础的队列与MR波谱（MEGA-PRESS）和静息态功能磁共振成像。PB与ACC中的GABA水平呈负相关（N = 221），与右侧ACC种子FC与右侧中央前回和双侧扣带回中后部呈正相关（N = 187）。此外，GABA浓度和FC呈负相关，FC介导GABA水平和PB之间的关联（N = 171）。我们的结果从最小的偏见，大规模的样本提供了新的见解，在青春期早期亲社会发展的神经代谢和神经功能的相关性。
Human prosocial behavior (PB) emerges in childhood and matures during adolescence. Previous task-related functional magnetic resonance imaging (fMRI) studies have reported involvement of the medial prefrontal cortex including the anterior cingulate cortex (ACC) in social cognition in adolescence. However, neurometabolic and functional connectivity (FC) basis of PB in early adolescence remains unclear. Here, we measured GABA levels in the ACC and FC in a subsample (aged 10.5–13.4 years) of a large-scale population-based cohort with MR spectroscopy (MEGA-PRESS) and resting-state fMRI. PB was negatively correlated with GABA levels in the ACC (N = 221), and positively correlated with right ACC-seeded FC with the right precentral gyrus and the bilateral middle and posterior cingulate gyrus (N = 187). Furthermore, GABA concentrations and this FC were negatively correlated, and the FC mediated the association between GABA levels and PB (N = 171). Our results from a minimally biased, large-scale sample provide new insights into the neurometabolic and neurofunctional correlates of prosocial development during early adolescence.