Prognostic impact of CD133 expression in gastric carcinoma.
Prognostic impact of CD133 expression in gastric carcinoma.
复制标题
DOI：
--
复制
发表时间：
2010-06
影响因子：
2
通讯作者：
S. Ishigami;S. Ueno;T. Arigami;Y. Uchikado;T. Setoyama;Hideo Arima;Y. Kita;H. Kurahara;H. Okumura;M. Matsumoto;Y. Kijima;S. Natsugoe
中科院分区：
文献类型：
--
作者：
S. Ishigami;S. Ueno;T. Arigami;Y. Uchikado;T. Setoyama;Hideo Arima;Y. Kita;H. Kurahara;H. Okumura;M. Matsumoto;Y. Kijima;S. Natsugoe
背景与目的CD133在癌细胞中的表达被认为是上皮恶性肿瘤中肿瘤干细胞（CSC）的一个假定标志物。评估了胃癌中CD133的表达，并阐明了CD133阳性胃癌的临床影响。患者和方法97例接受根治性胃切除术的胃癌患者入组。免疫组化法检测癌组织中CD133的表达。结果CD133的表达与肿瘤的范围和淋巴结的侵犯程度呈正相关。CD133表达显著影响患者术后结局。多因素分析显示CD 133阳性是独立的预后因素，其上级性优于浸润深度，与淋巴结转移相似（p<0.05）。结论CD133在胃癌患者中的轻度表达可能是一个有用的预后指标。进一步检测CD133与CSC标志物的关系可以预测胃癌的复发风险。
BACKGROUND AND AIM CD133 expression in cancer cells has been recognised as a putative cancer stem cell (CSC) marker in epithelial malignancies. CD133 expression was evaluated in gastric cancer and the clinical impact of CD133-positive gastric cancer was clarified. PATIENTS AND METHODS Ninety-seven gastric cancer patients who received curative gastrectomy were enrolled. CD133 expression in cancerous tissue was evaluated by immunohistochemistry. RESULTS CD133 expression positively correlated with tumour extension and the degree of nodal involvement. CD133 expression significantly affected patient postoperative outcome. Multivariate analysis revealed CD133 positivity as an independent prognostic factor superior to the depth of invasion and similar to nodal involvement in gastric cancer (p<0.05). CONCLUSION Even slight CD133 expression in gastric cancer patients may be a useful prognostic marker via CSC. Further examination of CD133 with respect to CSC markers can enable prediction of the recurrence risk of gastric cancer.