Effectiveness of Mycophenolate Mofetil in the Treatment of Pediatric Anti-NMDAR Encephalitis: A Retrospective Analysis of 6 Cases.
Effectiveness of Mycophenolate Mofetil in the Treatment of Pediatric Anti-NMDAR Encephalitis: A Retrospective Analysis of 6 Cases.
复制标题
吗替麦考酚酯治疗小儿抗NMDAR脑炎6例疗效回顾性分析。
DOI：
10.3389/fneur.2020.584446
复制
发表时间：
2020
影响因子：
3.4
通讯作者：
Liu SY
中科院分区：
文献类型：
--
作者：
Hao XS;Wang JT;Chen C;Hao YP;Liang JM;Liu SY
目的：探讨霉酚酸酯(MMF)作为二线药物治疗最常见、最严重的自身免疫性脑炎--抗N-甲基-D-天冬氨酸受体脑炎的有效性和安全性。方法：回顾分析吉林大学第一医院收治的6例抗NMDAR脑炎患儿的临床资料，评价霉酚酸酯的有效性和安全性。结果：6例抗NMDAR脑炎患儿在第2次或第3次治疗中接受了MMF治疗(3例对3例)。MMF起始时间为发病后平均19.2个月(6~39个月)，平均剂量为25.6 mg/kg(19.6~28.4 mg/kg)，疗程14个月(6~26个月)。只有两名患者在应用MMF后2周内出现一过性轻度腹泻。随访期间，1例在服用MMF期间复发，1例停用MMF，4例仍在服用MMF。结论：霉酚酸酯治疗NMDAR脑炎安全有效。MMF可用于已经复发或甚至可能在首次复发后复发的患者的复发预防选项之一。延迟使用可能是MMF失败的主要原因。
Objective: To explore the effectiveness and safety of mycophenolate mofetil (MMF) as a second-line medication in the treatment of anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis, the most common and severe autoimmune encephalitis. Methods: The clinical data of six children with anti-NMDAR encephalitis admitted to the First Hospital of Jilin University were retrospectively analyzed, and the effectiveness and safety of MMF were evaluated. Results: Six children with anti-NMDAR encephalitis were treated with MMF in the 2nd or 3rd treatment disease event (3 cases vs. 3 cases). MMF initiation was mean 19.2 months (range 6–39 months) after disease onset at a mean dose of 25.6 mg/kg (range 19.6–28.4 mg/kg) for 14 months (range 6–26 months). Only two patients had transient mild diarrhea within 2 weeks of MMF application. During follow-up, one patient relapsed whilst on MMF, one patient discontinued MMF, and 4 cases were still on MMF. Conclusion: The use of MMF in anti-NMDAR encephalitis may be effective and safe. MMF can be used as one of the relapse prevention options in patients who already have relapsed or possibly even after the first event. Delayed use may be the main reason for MMF failure.
登录
查看更多内容
影响因子：
0.5
作者：
Barbagallo M;Vitaliti G;Pavone P;Romano C;Lubrano R;Falsaperla R
通讯作者：
Falsaperla R
DOI：
10.1016/s1474-4422(15)00401-9
发表时间：
2016-04
期刊：
The Lancet. Neurology
影响因子：
--
作者：
Graus F;Titulaer MJ;Balu R;Benseler S;Bien CG;Cellucci T;Cortese I;Dale RC;Gelfand JM;Geschwind M;Glaser CA;Honnorat J;Höftberger R;Iizuka T;Irani SR;Lancaster E;Leypoldt F;Prüss H;Rae-Grant A;Reindl M;Rosenfeld MR;Rostásy K;Saiz A;Venkatesan A;Vincent A;Wandinger KP;Waters P;Dalmau J
通讯作者：
Dalmau J
影响因子：
6
作者：
Bartolini, Luca;Muscal, Eyal
通讯作者：
Muscal, Eyal
影响因子：
4
作者：
Zhou, Ji;Lu, Xiaopeng;Wu, Ye
通讯作者：
Wu, Ye
DOI：
10.1212/nxi.0000000000000633
发表时间：
2020-01-01
影响因子：
8.8
作者：
Xu, Xiaolu;Lu, Qiang;Guan, Hongzhi
通讯作者：
Guan, Hongzhi