IL-1β suppresses nephronectin expression in osteoblasts via ERK1/2 and JNK
IL-1β suppresses nephronectin expression in osteoblasts via ERK1/2 and JNK
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DOI：
10.1016/j.bbrc.2017.08.104
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发表时间：
2017-11-04
影响因子：
3.1
通讯作者：
Kamijo, Ryutaro
中科院分区：
文献类型：
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作者：
Iezumi, Yuka;Yamada, Atsushi;Kamijo, Ryutaro
肾连接素 (Npnt) 是一种细胞外基质蛋白，被认为在各种组织的发育及其功能中发挥着关键作用。在基础科学实验中，我们发现众所周知在炎症反应中具有重要作用的白细胞介素-1β（IL-1β）可抑制小鼠成骨细胞系 MOT3-E1 细胞中 Npnt 基因的表达。本研究的目的是研究成骨细胞中 IL-1β 调节 Npnt 基因表达的机制。 (C) 2017 Elsevier Inc. 保留所有权利。
Nephronectin (Npnt), an extracellular matrix protein, is considered to play critical roles in development of various tissues and their functions. In basic science experiments, we found that interleukin-1 beta (IL-1 beta), well known to have an important role in inflammatory response, inhibited Npnt gene expression in MOT3-E1 cells, a mouse osteoblastic cell line. The purpose of this study was to investigate mechanisms that govern the regulation of Npnt gene expression by IL-1 beta in osteoblasts. (C) 2017 Elsevier Inc. All rights reserved.